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Dayyih WA, Hamad M, Awwad AA, et al. A Liquid Chromatography-Tandem Mass Spectrometry Method for Evaluation of Two Brands of Enalapril 20 mg Tablets in Healthy Human Volunteers. J Anal Methods Chem. 2017;2017:8489471doi: 10.1155/2017/8489471.
Dayyih, W. A., Hamad, M., Awwad, A. A., Mallah, E., Zakarya, Z., Dayyih, A. A., & Arafat, T. (2017). A Liquid Chromatography-Tandem Mass Spectrometry Method for Evaluation of Two Brands of Enalapril 20 mg Tablets in Healthy Human Volunteers. Journal of analytical methods in chemistry, 20178489471. https://doi.org/10.1155/2017/8489471
Dayyih, Wael Abu, et al. "A Liquid Chromatography-Tandem Mass Spectrometry Method for Evaluation of Two Brands of Enalapril 20 mg Tablets in Healthy Human Volunteers." Journal of analytical methods in chemistry vol. 2017 (2017): 8489471. doi: https://doi.org/10.1155/2017/8489471
Dayyih WA, Hamad M, Awwad AA, Mallah E, Zakarya Z, Dayyih AA, Arafat T. A Liquid Chromatography-Tandem Mass Spectrometry Method for Evaluation of Two Brands of Enalapril 20 mg Tablets in Healthy Human Volunteers. J Anal Methods Chem. 2017;2017:8489471. doi: 10.1155/2017/8489471. Epub 2017 Aug 15. PMID: 28894622; PMCID: PMC5574226.
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J Anal Methods Chem. 2017;2017:8489471. doi: 10.1155/2017/8489471. Epub 2017 Aug 15.

A Liquid Chromatography-Tandem Mass Spectrometry Method for Evaluation of Two Brands of Enalapril 20 mg Tablets in Healthy Human Volunteers.

Journal of analytical methods in chemistry

Wael Abu Dayyih, Mohammed Hamad, Ahmad Abu Awwad, Eyad Mallah, Zainab Zakarya, Alice Abu Dayyih, Tawfiq Arafat

Affiliations

  1. Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan.
  2. Department of Basic Sciences, College of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
  3. Faculty of Chemistry, University of Duisburg-Essen, Essen, Germany.
  4. School of Chemistry, Biology and Pharmacy, Hochschule Fresenius University of Applied Sciences, Idstein, Germany.

PMID: 28894622 PMCID: PMC5574226 DOI: 10.1155/2017/8489471

Abstract

Enalapril is an angiotensin-converting enzyme inhibitor used for treatment of hypertension and chronic heart disease. Enalaprilat is its active metabolite responsible for the activity. This study aimed to develop and validate a method for enalapril and enalaprilat analysis and to determine the bioequivalence of two tablet formulae of enalapril. LC-MS/MS bioanalytical method was developed and validated and then applied to evaluate the bioavailability of two enalapril formulae. Antihyperglycemic sitagliptin was used as internal standard (IS). The method was accurate for the within- and between-days analysis, and precise CV% was <5%, being linear over the calibration range 1.0-200.0 ng/ml. Stability was >85% and the LOD was 0.907 and 0.910 ng/ml for enalapril and enalaprilat, respectively, and LLOQ was 1 ng/ml. The pharmacokinetic parameters

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