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Grønlund S, Mey K, Andersen E, et al. The true malignancy rate in 135 patients with preoperative diagnosis of a lateral neck cyst. Laryngoscope Investig Otolaryngol. 2016;1(4):78-82doi: 10.1002/lio2.23.
Grønlund, S., Mey, K., Andersen, E., & Rasmussen, E. R. (2016). The true malignancy rate in 135 patients with preoperative diagnosis of a lateral neck cyst. Laryngoscope investigative otolaryngology, 1(4), 78-82. https://doi.org/10.1002/lio2.23
Grønlund, Søren, et al. "The true malignancy rate in 135 patients with preoperative diagnosis of a lateral neck cyst." Laryngoscope investigative otolaryngology vol. 1,4 (2016): 78-82. doi: https://doi.org/10.1002/lio2.23
Grønlund S, Mey K, Andersen E, Rasmussen ER. The true malignancy rate in 135 patients with preoperative diagnosis of a lateral neck cyst. Laryngoscope Investig Otolaryngol. 2016 Jun 21;1(4):78-82. doi: 10.1002/lio2.23. eCollection 2016 Aug. PMID: 28894805; PMCID: PMC5510250.
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Laryngoscope Investig Otolaryngol. 2016 Jun 21;1(4):78-82. doi: 10.1002/lio2.23. eCollection 2016 Aug.

The true malignancy rate in 135 patients with preoperative diagnosis of a lateral neck cyst.

Laryngoscope investigative otolaryngology

Søren Grønlund, Kristianna Mey, Elo Andersen, Eva Rye Rasmussen

Affiliations

  1. Department of Otorhinolaryngology Hillerød Hospital Hillerød Denmark.
  2. Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Rigshospitalet and Gentofte Hospital, University of Copenhagen Copenhagen Denmark.
  3. Department of Oncology Herlev Hospital Denmark.
  4. Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Rigshospitalet, University of Copenhagen Copenhagen East Denmark.

PMID: 28894805 PMCID: PMC5510250 DOI: 10.1002/lio2.23

Abstract

OBJECTIVE: In this study, the true malignancy rate in 135 patients with a preoperative tentative diagnosis of a lateral neck cyst (LNC) was assessed. Furthermore, the sensitivity and specificity of fine needle aspiration of suspected LNC were evaluated and the diagnostic delay was analyzed.

STUDY DESIGN: This study was retrospective in design and included all patients who had undergone surgery for a suspected LNC in four secondary hospitals in the eastern regions of Denmark during the period of 2009 to 2012.

METHODS: One hundred thirty-five patients were identified and included by means of a search strategy for NOMECO surgical procedure codes KENB40A+B in the electronic surgical booking systems. Because the procedure codes also include median neck cysts and fistulas, the latter were excluded manually.

RESULTS: Of the 135 patients preoperatively diagnosed with LNC, a malignant postoperative histopathological diagnosis was revealed in 19 patients (14.4%). Of these, three individuals were between 35 to 40 years of age. In 17 cases, preoperative fine-needle aspiration biopsy showed benign cytology, whereas histopathology postoperatively proved to be malignant. This renders a sensitivity of 88.8% and a specificity of 60.0% for fine needle aspiration biopsy with regard to LNC diagnostics.

CONCLUSION: This study suggests that, for patients older than 35 years, a cystic lateral neck mass should be considered potentially malignant; by contrast, LNC is a diagnosis of exclusion. Any delay in treatment should be avoided until final histopathological diagnosis has been obtained. Arguably, all patients older than 35 years with a cystic lesion laterally on the neck should be included in the fast-track cancer referral program.

LEVEL OF EVIDENCE: 2b.

Keywords: Cysts; branchial; cervical; fine needle aspiration; malignant; metastasis

References

  1. J Oral Maxillofac Surg. 2007 Nov;65(11):2242-7 - PubMed
  2. Ann Otol Rhinol Laryngol. 2011 Jun;120(6):409-13 - PubMed
  3. Arch Pathol Lab Med. 2009 Nov;133(11):1798-803 - PubMed
  4. Arch Otolaryngol Head Neck Surg. 2009 Oct;135(10):1024-9 - PubMed
  5. Head Neck. 2006 Jul;28(7):633-8 - PubMed
  6. Head Neck Oncol. 2009 Apr 29;1:9 - PubMed
  7. GMS Curr Top Otorhinolaryngol Head Neck Surg. 2013 Dec 13;12:Doc04 - PubMed
  8. Laryngoscope. 2000 Oct;110(10 Pt 1):1637-41 - PubMed
  9. Head Neck. 2011 Nov;33(11):1569-75 - PubMed
  10. APMIS. 2010 Jun;118(6-7):510-9 - PubMed
  11. Head Neck. 2008 Sep;30(9):1246-52 - PubMed
  12. Laryngoscope. 2002 Nov;112(11):1983-7 - PubMed
  13. Q J Nucl Med Mol Imaging. 2011 Oct;55(5):500-8 - PubMed
  14. Am J Surg. 1990 May;159(5):482-5 - PubMed
  15. J Laryngol Otol. 1994 Dec;108(12):1068-71 - PubMed
  16. J Laryngol Otol. 2004 Dec;118(12):946-50 - PubMed
  17. Thyroid Res. 2008 Dec 06;1(1):8 - PubMed
  18. Am J Pathol. 1959 Mar-Apr;35(2):407-43 - PubMed
  19. Ann R Coll Surg Engl. 1999 Sep;81(5):296-8 - PubMed
  20. Oncol Lett. 2014 Jan;7(1):219-222 - PubMed
  21. AJR Am J Roentgenol. 2012 Aug;199(2):W216-21 - PubMed
  22. Head Neck. 2008 Jul;30(7):898-903 - PubMed
  23. Br J Cancer. 1999 Mar;79(9-10):1437-42 - PubMed
  24. Head Neck Pathol. 2012 Jul;6 Suppl 1:S25-40 - PubMed
  25. Laryngoscope. 1982 Jan;92(1):27-30 - PubMed

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