Display options
Cite
Mez J, Marden JR, Mukherjee S, et al. Alzheimer's disease genetic risk variants beyond . Alzheimers Dement (Amst). 2017;8:188-195doi: 10.1016/j.dadm.2017.07.002.
Mez, J., Marden, J. R., Mukherjee, S., Walter, S., Gibbons, L. E., Gross, A. L., Zahodne, L. B., Gilsanz, P., Brewster, P., Nho, K., Crane, P. K., Larson, E. B., & Glymour, M. M. (2017). Alzheimer's disease genetic risk variants beyond . Alzheimer's & dementia (Amsterdam, Netherlands), 8188-195. https://doi.org/10.1016/j.dadm.2017.07.002
Mez, Jesse, et al. "Alzheimer's disease genetic risk variants beyond ." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 8 (2017): 188-195. doi: https://doi.org/10.1016/j.dadm.2017.07.002
Mez J, Marden JR, Mukherjee S, Walter S, Gibbons LE, Gross AL, Zahodne LB, Gilsanz P, Brewster P, Nho K, Crane PK, Larson EB, Glymour MM. Alzheimer's disease genetic risk variants beyond . Alzheimers Dement (Amst). 2017 Aug 14;8:188-195. doi: 10.1016/j.dadm.2017.07.002. eCollection 2017. PMID: 28983503; PMCID: PMC5604953.
Copy Download .nbib Format: NLM
Share it on

Alzheimers Dement (Amst). 2017 Aug 14;8:188-195. doi: 10.1016/j.dadm.2017.07.002. eCollection 2017.

Alzheimer's disease genetic risk variants beyond .

Alzheimer's & dementia (Amsterdam, Netherlands)

Jesse Mez, Jessica R Marden, Shubhabrata Mukherjee, Stefan Walter, Laura E Gibbons, Alden L Gross, Laura B Zahodne, Paola Gilsanz, Paul Brewster, Kwangsik Nho, Paul K Crane, Eric B Larson, M Maria Glymour

Affiliations

  1. Alzheimer's Disease and Chronic Traumatic Encephalopathy Center, Boston University School of Medicine, Boston, MA, USA.
  2. Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
  3. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  4. Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
  5. Department of Medicine, University of Washington, Seattle, WA, USA.
  6. Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
  7. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and Johns Hopkins University Center on Aging and Health, Baltimore, MD, USA.
  8. Department of Psychology, University of Michigan, Ann Arbor, MI, USA.
  9. Institute on Aging & Lifelong Health, University of Victoria, Victoria, BC, Canada.
  10. Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
  11. Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.

PMID: 28983503 PMCID: PMC5604953 DOI: 10.1016/j.dadm.2017.07.002

Abstract

INTRODUCTION: We hypothesized that, like apolipoprotein E (

METHODS: We used a weighted genetic risk score (GRS) from 21 non-

RESULTS: Higher GRS predicted mortality (hazard ratio = 1.05; 95% confidence interval: 1.00-1.10,

DISCUSSION: Non-

Keywords: APOE; Adult Changes in Thought (ACT); Alzheimer's disease; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE); Collider stratification bias; Genetic risk score; Genome-wide association study (GWAS); Health and Retirement Study (HRS); Longevity; Mortality; Selection bias; Survival analysis; Survivor bias

References

  1. Bioinformatics. 2008 Dec 15;24(24):2938-9 - PubMed
  2. Int J Epidemiol. 2014 Apr;43(2):576-85 - PubMed
  3. Alzheimers Dement. 2015 Mar;11(3):332-84 - PubMed
  4. Hum Genet. 1996 Mar;97(3):319-23 - PubMed
  5. J Gerontol A Biol Sci Med Sci. 2015 Jan;70(1):110-8 - PubMed
  6. Stat Med. 2004 Jan 30;23(2):241-56 - PubMed
  7. Atherosclerosis. 2001 Feb 15;154(3):529-37 - PubMed
  8. Alzheimers Dement. 2015 Dec;11(12 ):1439-1451 - PubMed
  9. Am J Epidemiol. 2007 Jun 1;165(11):1239-46; author reply 1247 - PubMed
  10. Brain Behav. 2014 Sep;4(5):687-97 - PubMed
  11. PLoS Genet. 2014 Jan 30;10(1):e1004141 - PubMed
  12. Neurobiol Aging. 2009 Oct;30(10):1545-51 - PubMed
  13. PLoS One. 2012;7(1):e29848 - PubMed
  14. Int J Epidemiol. 2013 Aug;42(4):1134-44 - PubMed
  15. J Alzheimers Dis. 2015;45(2):651-8 - PubMed
  16. Int Psychogeriatr. 1994 Spring;6(1):45-58; discussion 62 - PubMed
  17. Nat Genet. 2013 Dec;45(12):1452-8 - PubMed
  18. Paediatr Perinat Epidemiol. 2009 Sep;23(5):394-402 - PubMed
  19. Aging Cell. 2011 Aug;10 (4):686-98 - PubMed
  20. J Am Geriatr Soc. 2005 Jun;53(6):935-42 - PubMed
  21. PLoS Genet. 2012;8(3):e1002607 - PubMed
  22. Am J Epidemiol. 2016 Sep 1;184(5):378-87 - PubMed
  23. Epidemiology. 2004 Sep;15(5):615-25 - PubMed
  24. Mech Ageing Dev. 2011 Jun-Jul;132(6-7):324-30 - PubMed
  25. Alzheimer Dis Assoc Disord. 2013 Jul-Sep;27(3):207-12 - PubMed
  26. Epidemiol Rev. 1998;20(1):81-90 - PubMed

Publication Types

Grant support