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Linciano P, Dawson A, Pöhner I, et al. Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit . ACS Omega. 2017;2(9):5666-5683doi: 10.1021/acsomega.7b00473.
Linciano, P., Dawson, A., Pöhner, I., Costa, D. M., Sá, M. S., Cordeiro-da-Silva, A., Luciani, R., Gul, S., Witt, G., Ellinger, B., Kuzikov, M., Gribbon, P., Reinshagen, J., Wolf, M., Behrens, B., Hannaert, V., Michels, P. A. M., Nerini, E., Pozzi, C., di Pisa, F., Landi, G., Santarem, N., Ferrari, S., Saxena, P., Lazzari, S., Cannazza, G., Freitas-Junior, L. H., Moraes, C. B., Pascoalino, B. S., Alcântara, L. M., Bertolacini, C. P., Fontana, V., Wittig, U., Müller, W., Wade, R. C., Hunter, W. N., Mangani, S., Costantino, L., & Costi, M. P. (2017). Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit . ACS omega, 2(9), 5666-5683. https://doi.org/10.1021/acsomega.7b00473
Linciano, Pasquale, et al. "Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit ." ACS omega vol. 2,9 (2017): 5666-5683. doi: https://doi.org/10.1021/acsomega.7b00473
Linciano P, Dawson A, Pöhner I, Costa DM, Sá MS, Cordeiro-da-Silva A, Luciani R, Gul S, Witt G, Ellinger B, Kuzikov M, Gribbon P, Reinshagen J, Wolf M, Behrens B, Hannaert V, Michels PAM, Nerini E, Pozzi C, di Pisa F, Landi G, Santarem N, Ferrari S, Saxena P, Lazzari S, Cannazza G, Freitas-Junior LH, Moraes CB, Pascoalino BS, Alcântara LM, Bertolacini CP, Fontana V, Wittig U, Müller W, Wade RC, Hunter WN, Mangani S, Costantino L, Costi MP. Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit . ACS Omega. 2017 Sep 30;2(9):5666-5683. doi: 10.1021/acsomega.7b00473. Epub 2017 Sep 11. PMID: 28983525; PMCID: PMC5623949.
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ACS Omega. 2017 Sep 30;2(9):5666-5683. doi: 10.1021/acsomega.7b00473. Epub 2017 Sep 11.

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit .

ACS omega

Pasquale Linciano, Alice Dawson, Ina Pöhner, David M Costa, Monica S Sá, Anabela Cordeiro-da-Silva, Rosaria Luciani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Philip Gribbon, Jeanette Reinshagen, Markus Wolf, Birte Behrens, Véronique Hannaert, Paul A M Michels, Erika Nerini, Cecilia Pozzi, Flavio di Pisa, Giacomo Landi, Nuno Santarem, Stefania Ferrari, Puneet Saxena, Sandra Lazzari, Giuseppe Cannazza, Lucio H Freitas-Junior, Carolina B Moraes, Bruno S Pascoalino, Laura M Alcântara, Claudia P Bertolacini, Vanessa Fontana, Ulrike Wittig, Wolfgang Müller, Rebecca C Wade, William N Hunter, Stefano Mangani, Luca Costantino, Maria P Costi

Affiliations

  1. Dipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
  2. Biological Chemistry & Drug Discovery, School of Life Sciences, The Wellcome Trust Building, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  3. Molecular and Cellular Modeling Group and Scientific Databases and Visualization (SDBV) Group, Heidelberg Institute for Theoretical Studies, Schloss-Wolfsbrunnenweg 35, D-69118 Heidelberg, Germany.
  4. Instituto de Investigação e Inovação em Saúde, Instituto de Biologia Molecular e Celular, and Departamento de Ciências Biológicas, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
  5. Fraunhofer-IME SP, Schnackenburgallee 114, D-22525 Hamburg, Germany.
  6. Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium.
  7. University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
  8. Laboratório Nacional de Biociências CNPEM, Centro Nacional de Pesquisa em Energia e Materials, Rua Giuseppe Máximo Scolfaro, 10.000, CEP 13083-970 Campinas/SP, Brasil.
  9. Center for Molecular Biology (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany.
  10. Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Im Neuenheimer Feld 205, D-69120 Heidelberg, Germany.

PMID: 28983525 PMCID: PMC5623949 DOI: 10.1021/acsomega.7b00473

Abstract

Pteridine reductase-1 (PTR1) is a promising drug target for the treatment of trypanosomiasis. We investigated the potential of a previously identified class of thiadiazole inhibitors of

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