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Tipirneni KE, Woodworth BA. Medical and Surgical Advancements in the Management of Cystic Fibrosis Chronic Rhinosinusitis. Curr Otorhinolaryngol Rep. 2017;5(1):24-34doi: 10.1007/s40136-017-0139-3.
Tipirneni, K. E., & Woodworth, B. A. (2017). Medical and Surgical Advancements in the Management of Cystic Fibrosis Chronic Rhinosinusitis. Current otorhinolaryngology reports, 5(1), 24-34. https://doi.org/10.1007/s40136-017-0139-3
Tipirneni, Kiranya E, and Woodworth, Bradford A. "Medical and Surgical Advancements in the Management of Cystic Fibrosis Chronic Rhinosinusitis." Current otorhinolaryngology reports vol. 5,1 (2017): 24-34. doi: https://doi.org/10.1007/s40136-017-0139-3
Tipirneni KE, Woodworth BA. Medical and Surgical Advancements in the Management of Cystic Fibrosis Chronic Rhinosinusitis. Curr Otorhinolaryngol Rep. 2017 Mar;5(1):24-34. doi: 10.1007/s40136-017-0139-3. Epub 2017 Feb 21. PMID: 28989817; PMCID: PMC5626435.
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Curr Otorhinolaryngol Rep. 2017 Mar;5(1):24-34. doi: 10.1007/s40136-017-0139-3. Epub 2017 Feb 21.

Medical and Surgical Advancements in the Management of Cystic Fibrosis Chronic Rhinosinusitis.

Current otorhinolaryngology reports

Kiranya E Tipirneni, Bradford A Woodworth

Affiliations

  1. Department of Surgery, University of Alabama at Birmingham.
  2. Department of Otolaryngology, University of Alabama at Birmingham.

PMID: 28989817 PMCID: PMC5626435 DOI: 10.1007/s40136-017-0139-3

Abstract

PURPOSE OF REVIEW: The purpose of this review is to provide otolaryngologists with the most up-to-date advancements in both the medical and surgical management of CF-related sinus disease.

RECENT FINDINGS: Recent studies have supported more aggressive CRS management, often with a combination of both medical and surgical therapies. Comprehensive treatment strategies have been shown to reduce hospital admissions secondary to pulmonary exacerbations in addition to improving CRS symptoms. Still, current management strategies are lacking in both high-level evidence and standardized guidelines.

SUMMARY: The unified airway model describes the bi-directional relationship between the upper and lower airways as a single functional unit and suggests that CRS may play a pivotal role in both the development and progression of lower airway disease. Current strategies for CF CRS focus primarily on amelioration of symptoms with antibiotics, nasal saline and/or topical medicated irrigations, and surgery. However, there are no definitive management guidelines and there remains a persistent need for additional studies. Nevertheless, otolaryngologists have a significant role in the overall management of CF, which requires a multi-disciplinary approach and a combination of both surgical and medical interventions for optimal outcomes of airway disease. Here we present a review of currently available literature and summarize medical and surgical therapies best suited for the management of CF-related sinus disease.

Keywords: CFTR; chronic sinusitis; cystic fibrosis; drug therapy; endoscopic sinus surgery; ivacaftor; modified medial maxillectomy; sinusitis; surgical therapy

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