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Nakatake R, Ishizaki M, Matui K, et al. Combination therapies for primary hepatic neuroendocrine carcinoma: a case report. Surg Case Rep. 2017;3(1):102doi: 10.1186/s40792-017-0378-z.
Nakatake, R., Ishizaki, M., Matui, K., Yanagimoto, H., Inoue, K., Kaibori, M., Kawaguchi, Y., & Kon, M. (2017). Combination therapies for primary hepatic neuroendocrine carcinoma: a case report. Surgical case reports, 3(1), 102. https://doi.org/10.1186/s40792-017-0378-z
Nakatake, Richi, et al. "Combination therapies for primary hepatic neuroendocrine carcinoma: a case report." Surgical case reports vol. 3,1 (2017): 102. doi: https://doi.org/10.1186/s40792-017-0378-z
Nakatake R, Ishizaki M, Matui K, Yanagimoto H, Inoue K, Kaibori M, Kawaguchi Y, Kon M. Combination therapies for primary hepatic neuroendocrine carcinoma: a case report. Surg Case Rep. 2017 Sep 11;3(1):102. doi: 10.1186/s40792-017-0378-z. PMID: 28895097; PMCID: PMC5593802.
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Surg Case Rep. 2017 Sep 11;3(1):102. doi: 10.1186/s40792-017-0378-z.

Combination therapies for primary hepatic neuroendocrine carcinoma: a case report.

Surgical case reports

Richi Nakatake, Morihiko Ishizaki, Kosuke Matui, Hiroaki Yanagimoto, Kentaro Inoue, Masaki Kaibori, Yusai Kawaguchi, Masanori Kon

Affiliations

  1. Department of Surgery, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan. [email protected].
  2. Department of Surgery, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.

PMID: 28895097 PMCID: PMC5593802 DOI: 10.1186/s40792-017-0378-z

Abstract

BACKGROUND: Primary hepatic neuroendocrine carcinomas are extremely rare. Because of the rarity of PHNEC, its clinical features and treatment outcomes are not well understood. A proper diagnosis and the correct therapeutic approach therefore remain clinically challenging.

CASE PRESENTATION: A 67-year-old man was admitted to our department because of a liver tumor. Computed tomography revealed a single liver tumor 50 mm in diameter and located in the S3 region. Biopsy and imaging findings resulted in a diagnosis of primary hepatic neuroendocrine carcinoma. Left lateral segmentectomy was performed. Immunohistochemically, the tumor cells were positive for synaptophysin, chromogranin A, and CD56. Ki-67 was positive in > 90% of the tumor cells. The final diagnosis was primary hepatic neuroendocrine carcinoma. The patient suffered two episodes of lymph node recurrence. Nonetheless, the tumor was excised to prolong survival. Thus, after lymphadenectomy, he received adjuvant chemotherapy for 6 months. Two years after surgery, the patient remains alive and in good general condition.

CONCLUSIONS: In most cases, primary hepatic neuroendocrine carcinoma, while extremely rare, has a poor prognosis. At present, surgical resection is a priority for curative treatment, but in patients with recurrence, combined therapies are recommended.

Keywords: Hepatectomy; Liver resection; Primary hepatic neuroendocrine carcinoma

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