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Neelaveni K, Kumar KVSH, Sahay R, et al. Postpartum Follow-up in Women Diagnosed with Subclinical Hypothyroidism during Pregnancy. Indian J Endocrinol Metab. 2017;21(5):699-702doi: 10.4103/ijem.IJEM_452_16.
Neelaveni, K., Kumar, K. V. S. H., Sahay, R., & Ramesh, J. (2017). Postpartum Follow-up in Women Diagnosed with Subclinical Hypothyroidism during Pregnancy. Indian journal of endocrinology and metabolism, 21(5), 699-702. https://doi.org/10.4103/ijem.IJEM_452_16
Neelaveni, K, et al. "Postpartum Follow-up in Women Diagnosed with Subclinical Hypothyroidism during Pregnancy." Indian journal of endocrinology and metabolism vol. 21,5 (2017): 699-702. doi: https://doi.org/10.4103/ijem.IJEM_452_16
Neelaveni K, Kumar KVSH, Sahay R, Ramesh J. Postpartum Follow-up in Women Diagnosed with Subclinical Hypothyroidism during Pregnancy. Indian J Endocrinol Metab. 2017 Sep-Oct;21(5):699-702. doi: 10.4103/ijem.IJEM_452_16. PMID: 28989877; PMCID: PMC5628539.
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Indian J Endocrinol Metab. 2017 Sep-Oct;21(5):699-702. doi: 10.4103/ijem.IJEM_452_16.

Postpartum Follow-up in Women Diagnosed with Subclinical Hypothyroidism during Pregnancy.

Indian journal of endocrinology and metabolism

K Neelaveni, K V S Hari Kumar, Rakesh Sahay, Jayanthy Ramesh

Affiliations

  1. Department of Endocrinology, Osmania Medical College, Hyderabad, Telangana, India.
  2. Department of Endocrinology, Army Hospital (R and R), New Delhi, India.
  3. Department of Endocrinology, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India.

PMID: 28989877 PMCID: PMC5628539 DOI: 10.4103/ijem.IJEM_452_16

Abstract

BACKGROUND: Management guidelines about the thyroid disease in pregnancy are silent about the postpartum course of new onset subclinical hypothyroidism (SCH). Hence, we analyzed the 2 years outcome of SCH diagnosed during pregnancy.

MATERIALS AND METHODS: We conducted this retrospective study using the medical records of patients with new onset SCH during pregnancy between 2010 and 2013 (

RESULTS: A total of 559 (77.8%) women stopped levothyroxine after delivery, and the final follow-up data were available for 467 patients only. At the end of 2 years, 384 (82.2%) remained euthyroid, and the remaining 83 (17.8%) developed hypothyroidism. SCH and overt hypothyroidism were seen in 22 and 61 patients, respectively. Group 2 patients had higher mean age (25.5 vs. 23.6 years), goiter (51 vs. 2%), initial thyroid stimulating hormone (7.9 vs. 5.1 μIU/mL), and thyroid antibody positivity (76 vs. 13%) (

CONCLUSION: The majority of patients with SCH during pregnancy remain euthyroid after delivery. Advanced age, goiter, positive family history, and thyroid autoimmunity increase the future risk of hypothyroidism in patients with SCH diagnosed during pregnancy.

Keywords: Autoimmunity; pregnancy; subclinical hypothyroidism; thyroid

Conflict of interest statement

There are no conflicts of interest.

References

  1. J Clin Endocrinol Metab. 2010 Sep;95(9):E44-8 - PubMed
  2. Eur J Endocrinol. 2009 Jun;160(6):985-91 - PubMed
  3. J Obstet Gynaecol India. 2014 Dec;64(6):394-9 - PubMed
  4. J Clin Endocrinol Metab. 2010 Sep;95(9):4227-34 - PubMed
  5. J Clin Endocrinol Metab. 2004 Oct;89(10):4890-7 - PubMed
  6. Thyroid. 1992 Spring;2(1):65-70 - PubMed
  7. J Womens Health (Larchmt). 2009 Nov;18(11):1847-56 - PubMed
  8. Hum Reprod Update. 2016 Jun;22(4):532-3 - PubMed
  9. J Clin Endocrinol Metab. 2013 Dec;98(12):E1941-5 - PubMed
  10. Indian J Endocrinol Metab. 2013 Mar;17(2):281-4 - PubMed
  11. J Clin Endocrinol Metab. 2002 Jul;87(7):3221-6 - PubMed
  12. N Engl J Med. 1999 Aug 19;341(8):549-55 - PubMed
  13. Arch Intern Med. 2008 Aug 11;168(15):1657-63 - PubMed
  14. Clin Endocrinol (Oxf). 1995 Jul;43(1):55-68 - PubMed
  15. J Assoc Physicians India. 2009 Oct;57:691-3 - PubMed
  16. J Clin Endocrinol Metab. 2012 Aug;97(8):2543-65 - PubMed
  17. Thyroid. 2011 Oct;21(10):1081-125 - PubMed
  18. Indian J Endocrinol Metab. 2013 Mar;17(2):294-7 - PubMed
  19. Endocr Rev. 2010 Oct;31(5):702-55 - PubMed
  20. Eur Thyroid J. 2014 Jun;3(2):76-94 - PubMed
  21. Indian J Endocrinol Metab. 2015 May-Jun;19(3):416-9 - PubMed
  22. J Clin Endocrinol Metab. 2012 Dec;97(12):4464-72 - PubMed

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