Display options
Cite
Barba I, Andrés M, Garcia-Dorado D. Metabolomics and Heart Diseases: From Basic to Clinical Approach. Curr Med Chem. 2019;26(1):46-59doi: 10.2174/0929867324666171006151408.
Barba, I., Andrés, M., & Garcia-Dorado, D. (2019). Metabolomics and Heart Diseases: From Basic to Clinical Approach. Current medicinal chemistry, 26(1), 46-59. https://doi.org/10.2174/0929867324666171006151408
Barba, Ignasi, et al. "Metabolomics and Heart Diseases: From Basic to Clinical Approach." Current medicinal chemistry vol. 26,1 (2019): 46-59. doi: https://doi.org/10.2174/0929867324666171006151408
Barba I, Andrés M, Garcia-Dorado D. Metabolomics and Heart Diseases: From Basic to Clinical Approach. Curr Med Chem. 2019;26(1):46-59. doi: 10.2174/0929867324666171006151408. PMID: 28990507.
Copy Download .nbib Format: NLM
Share it on

Curr Med Chem. 2019;26(1):46-59. doi: 10.2174/0929867324666171006151408.

Metabolomics and Heart Diseases: From Basic to Clinical Approach.

Current medicinal chemistry

Ignasi Barba, Mireia Andrés, David Garcia-Dorado

Affiliations

  1. Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain.
  2. Centro de Investigacion Biomedica en Red sobre Enfermedades Cardiovasculares (CIBER-CV), Madrid, Spain.

PMID: 28990507 DOI: 10.2174/0929867324666171006151408

Abstract

BACKGROUND: The field of metabolomics has been steadily increasing in size for the last 15 years. Advances in analytical and statistical methods have allowed metabolomics to flourish in various areas of medicine. Cardiovascular diseases are some of the main research targets in metabolomics, due to their social and medical relevance, and also to the important role metabolic alterations play in their pathogenesis and evolution. Metabolomics has been applied to the full spectrum of cardiovascular diseases: from patient risk stratification to myocardial infarction and heart failure. However - despite the many proof-ofconcept studies describing the applicability of metabolomics in the diagnosis, prognosis and treatment evaluation in cardiovascular diseases - it is not yet used in routine clinical practice. Recently, large phenome centers have been established in clinical environments, and it is expected that they will provide definitive proof of the applicability of metabolomics in clinical practice. But there is also room for small and medium size centers to work on uncommon pathologies or to resolve specific but relevant clinical questions.

OBJECTIVES: In this review, we will introduce metabolomics, cover the metabolomic work done so far in the area of cardiovascular diseases.

CONCLUSION: The cardiovascular field has been at the forefront of metabolomics application and it should lead the transfer to the clinic in the not so distant future.

Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Keywords: 1H NMR; Metabolic profiling; cardiovascular diseases; metabolic phenotyping; metabolomics; precision medicine.

MeSH terms

Publication Types