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J Clin Biochem Nutr. 2017 Sep;61(2):91-99. doi: 10.3164/jcbn.16-117. Epub 2017 Jul 28.

Dietary phosphate exacerbates intestinal inflammation in experimental colitis.

Journal of clinical biochemistry and nutrition

Kohei Sugihara, Masashi Masuda, Mari Nakao, Maerjianghan Abuduli, Yukiko Imi, Naoko Oda, Toshiya Okahisa, Hironori Yamamoto, Eiji Takeda, Yutaka Taketani

Affiliations

  1. Departments of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
  2. Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
  3. Department of Health and Nutrition, Faculty of Human Life, Jin-ai University, Fukui 915-8586, Japan.

PMID: 28955125 PMCID: PMC5612814 DOI: 10.3164/jcbn.16-117

Abstract

The recent widespread consumption of Western diets and food additives worldwide is associated with excessive inorganic phosphate intake. However, researchers have known little about the impact of dietary phosphate intake on the development of inflammatory bowel disease to date. In this study, we investigated the effects of dietary phosphate on intestinal inflammation in experimental colitis. Sprague-Dawley rats were fed different phosphate diets (0.5%, 1.0% and 1.5% phosphate) with or without dextran sulfate sodium. For

Keywords: DSS-induced colitis; NF-κB; ROS; dietary Pi; proinflammatory cytokine

Conflict of interest statement

No potential conflicts of interest were disclosed.

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