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Niegawa T, Takitani K, Takaya R, et al. Evaluation of uric acid levels, thyroid function, and anthropometric parameters in Japanese children with Down syndrome. J Clin Biochem Nutr. 2017;61(2):146-152doi: 10.3164/jcbn.17-55.
Niegawa, T., Takitani, K., Takaya, R., Ishiro, M., Kuroyanagi, Y., Okasora, K., Minami, Y., Matsuda, T., & Tamai, H. (2017). Evaluation of uric acid levels, thyroid function, and anthropometric parameters in Japanese children with Down syndrome. Journal of clinical biochemistry and nutrition, 61(2), 146-152. https://doi.org/10.3164/jcbn.17-55
Niegawa, Tomomi, et al. "Evaluation of uric acid levels, thyroid function, and anthropometric parameters in Japanese children with Down syndrome." Journal of clinical biochemistry and nutrition vol. 61,2 (2017): 146-152. doi: https://doi.org/10.3164/jcbn.17-55
Niegawa T, Takitani K, Takaya R, Ishiro M, Kuroyanagi Y, Okasora K, Minami Y, Matsuda T, Tamai H. Evaluation of uric acid levels, thyroid function, and anthropometric parameters in Japanese children with Down syndrome. J Clin Biochem Nutr. 2017 Sep;61(2):146-152. doi: 10.3164/jcbn.17-55. Epub 2017 Aug 18. PMID: 28955133; PMCID: PMC5612823.
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J Clin Biochem Nutr. 2017 Sep;61(2):146-152. doi: 10.3164/jcbn.17-55. Epub 2017 Aug 18.

Evaluation of uric acid levels, thyroid function, and anthropometric parameters in Japanese children with Down syndrome.

Journal of clinical biochemistry and nutrition

Tomomi Niegawa, Kimitaka Takitani, Ryuzo Takaya, Manabu Ishiro, Yuichi Kuroyanagi, Keisuke Okasora, Yukako Minami, Takuya Matsuda, Hiroshi Tamai

Affiliations

  1. Department of Pediatrics, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan.
  2. Department of Pediatrics, Saiseikai Ibaraki Hospital, 2-1-45 Mitsukeyama, Ibaraki, Osaka 567-0035, Japan.
  3. Department of Pediatrics, Saiseikai Suita Hospital, 1-2 Kawazonocho, Suita, Osaka 564-0013, Japan.
  4. Department of Pediatrics, Hirakata City Hospital, 2-14-1 Kinyahonmachi, Hirakata, Osaka 573-1013, Japan.

PMID: 28955133 PMCID: PMC5612823 DOI: 10.3164/jcbn.17-55

Abstract

Down syndrome, caused by trisomy 21, is characterized by congenital abnormalities as well as mental retardation. From the neonatal stage through adolescence, patients with Down syndrome often have several complications. Thus, it is important to attain knowledge of the prevalence of these comorbidities in children with Down syndrome. We, therefore, evaluated the biochemical data, thyroid function, and anthropometric parameters, and analyzed the association among them in Japanese children and early adolescents with Down syndrome. There was no difference in the prevalence of obesity and overweight between boys and girls. The level of uric acid was higher in boys than in girls. Moreover, the prevalence of hyperuricemia was also higher in boys than in girls (approximately 32% and 10%, respectively). The prevalence of subclinical hypothyroidism in children with Down syndrome was approximately 20%, with no significant sex differences. The levels of uric acid and dehydroepiandrosterone-sulfate were positively associated with age, while the levels of thyroid-stimulating hormone and free thyroxine had a negative association with age. Overall, children with Down syndrome, exhibit a higher incidence of hyperuricemia. Therefore, uric acid levels, as well as thyroid function, from childhood to early adulthood should be monitored in this patient cohort.

Keywords: Down syndrome; anthropometry; thyroid function; uric acid

Conflict of interest statement

No potential conflicts of interest were disclosed.

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