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Wassef MA, Fouad H, Sabry D, et al. Therapeutic efficacy of differentiated versus undifferentiated mesenchymal stem cells in experimental type I diabetes in rat. Biochem Biophys Rep. 2016;5:468-475doi: 10.1016/j.bbrep.2016.02.001.
Wassef, M. A., Fouad, H., Sabry, D., Afifi, N., Abbas, A. M., Mostafa, W., & Ahmed, S. H. (2016). Therapeutic efficacy of differentiated versus undifferentiated mesenchymal stem cells in experimental type I diabetes in rat. Biochemistry and biophysics reports, 5468-475. https://doi.org/10.1016/j.bbrep.2016.02.001
Wassef, M A, et al. "Therapeutic efficacy of differentiated versus undifferentiated mesenchymal stem cells in experimental type I diabetes in rat." Biochemistry and biophysics reports vol. 5 (2016): 468-475. doi: https://doi.org/10.1016/j.bbrep.2016.02.001
Wassef MA, Fouad H, Sabry D, Afifi N, Abbas AM, Mostafa W, Ahmed SH. Therapeutic efficacy of differentiated versus undifferentiated mesenchymal stem cells in experimental type I diabetes in rat. Biochem Biophys Rep. 2016 Feb 09;5:468-475. doi: 10.1016/j.bbrep.2016.02.001. eCollection 2016 Mar. PMID: 28955854; PMCID: PMC5600460.
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Biochem Biophys Rep. 2016 Feb 09;5:468-475. doi: 10.1016/j.bbrep.2016.02.001. eCollection 2016 Mar.

Therapeutic efficacy of differentiated versus undifferentiated mesenchymal stem cells in experimental type I diabetes in rat.

Biochemistry and biophysics reports

M A Wassef, H Fouad, D Sabry, N Afifi, A M Abbas, W Mostafa, S H Ahmed

Affiliations

  1. Medical Biochemistry, Faculty of Medicine, Cairo University, POB 11562, Egypt.
  2. Biochemistry, Hail University, Faculty of Pharmacy, Saudi Arabia.
  3. Histology Departments, Faculty of Medicine, Cairo University, POB 11562, Egypt.
  4. Faculty of Medicine, Cairo University, POB 11562, Egypt.
  5. Laboratory Technology Department, Faculty of Applied Medical Science, Misr University of Science and Technology, Egypt.

PMID: 28955854 PMCID: PMC5600460 DOI: 10.1016/j.bbrep.2016.02.001

Abstract

Selective MSCs differentiation protocol into pancreatic beta cells was conducted in the present study using exendin-4 and TGF-beta. Differentiated and undifferentiated MSCs were assessed in experimental type I diabetes in rats. Ninety female white albino rats were included in the study and divided equally (n=15/group) into 6 groups: healthy control, healthy control rats received acellular tissue culture medium, diabetic rats, diabetic rats received acellular tissue culture medium, diabetic rats received undifferentiated MSCs and diabetic rats received differentiated MSCs. Therapeutic efficacy of undifferentiated versus differentiated MSCs was evaluated via assessment of quantitative gene expressions of

Keywords: Exendin-4; Experimental diabetes; MSCs; TGF-beta

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