Display options
Cite
Saito N, Kimura S, Miyamoto T, et al. Macrophage ubiquitin-specific protease 2 modifies insulin sensitivity in obese mice. Biochem Biophys Rep. 2017;9:322-329doi: 10.1016/j.bbrep.2017.01.009.
Saito, N., Kimura, S., Miyamoto, T., Fukushima, S., Amagasa, M., Shimamoto, Y., Nishioka, C., Okamoto, S., Toda, C., Washio, K., Asano, A., Miyoshi, I., Takahashi, E., & Kitamura, H. (2017). Macrophage ubiquitin-specific protease 2 modifies insulin sensitivity in obese mice. Biochemistry and biophysics reports, 9322-329. https://doi.org/10.1016/j.bbrep.2017.01.009
Saito, Natsuko, et al. "Macrophage ubiquitin-specific protease 2 modifies insulin sensitivity in obese mice." Biochemistry and biophysics reports vol. 9 (2017): 322-329. doi: https://doi.org/10.1016/j.bbrep.2017.01.009
Saito N, Kimura S, Miyamoto T, Fukushima S, Amagasa M, Shimamoto Y, Nishioka C, Okamoto S, Toda C, Washio K, Asano A, Miyoshi I, Takahashi E, Kitamura H. Macrophage ubiquitin-specific protease 2 modifies insulin sensitivity in obese mice. Biochem Biophys Rep. 2017 Jan 26;9:322-329. doi: 10.1016/j.bbrep.2017.01.009. eCollection 2017 Mar. PMID: 28956020; PMCID: PMC5614627.
Copy Download .nbib Format: NLM
Share it on

Biochem Biophys Rep. 2017 Jan 26;9:322-329. doi: 10.1016/j.bbrep.2017.01.009. eCollection 2017 Mar.

Macrophage ubiquitin-specific protease 2 modifies insulin sensitivity in obese mice.

Biochemistry and biophysics reports

Natsuko Saito, Shunsuke Kimura, Tomomi Miyamoto, Sanae Fukushima, Misato Amagasa, Yoshinori Shimamoto, Chieko Nishioka, Shiki Okamoto, Chitoku Toda, Kohei Washio, Atsushi Asano, Ichiro Miyoshi, Eiki Takahashi, Hiroshi Kitamura

Affiliations

  1. Laboratory of Veterinary Physiology, Department of Veterinary Medicine, and Laboratory of Animal Therapeutics, Japan.
  2. Laboratory of Histology and Cytology, Department of Functional Morphology, Graduate School of Medical Sciences, Hokkaido University, Kita15, Nishi7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan.
  3. Department of Comparative and Experimental Medicine, Graduate School of Medicine, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.
  4. Research Resources Center, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
  5. Department of Veterinary Science, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Ebetsu, Hokkaido 069-8501, Japan.
  6. Division of Endocrinology and Metabolism, National Institute for Physiological Sciences, 38 Nishigonaka Myodaiji, Okazaki, Aichi 444-8585, Japan.
  7. Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8063, USA.
  8. Laboratory of Laboratory Animal, Department of Basic Veterinary Science, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.

PMID: 28956020 PMCID: PMC5614627 DOI: 10.1016/j.bbrep.2017.01.009

Abstract

We previously reported that ubiquitin-specific protease (USP) 2 in macrophages down-regulates genes associated with metabolic diseases, suggesting a putative anti-diabetic role for USP2 in macrophages. In this study, we evaluate this role at both cellular and individual levels. Isolated macrophages forcibly expressing

Keywords: DMEM, Dulbecco's modified Eagle medium; Diabetes; ELISA, enzyme-linked immunosorbent assay; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; HFD, high-fat diet; HOMA-IR, homeostatic model assessment as an index of insulin resistance; IL, interleukin; IR, insulin receptor; IRS, insulin receptor substrate; Insulin; KD, knock down; KO, knockout; Macrophage; NCD, normal chow diet; NEFA, nonesterified fatty acid; Obesity; PDK, phosphoinositide-dependent kinase; PI3K, phosphatidylinositol 3-phosphate kinase; SOCS, suppressor of cytokine signaling; T2DM, type 2 diabetes mellitus; Tg, transgenic; USP; USP, ubiquitin-specific protease; pAkt, phosphorylated Akt; pIRβ, phosphorylated insulin receptor β chain

References

  1. Diabetes. 2005 Apr;54(4):952-8 - PubMed
  2. FASEB J. 2013 Dec;27(12 ):4940-53 - PubMed
  3. Adipocyte. 2013 Oct 1;2(4):227-36 - PubMed
  4. Diabetes. 2013 Jan;62(1):56-64 - PubMed
  5. J Immunol. 2014 Sep 1;193(5):2230-7 - PubMed
  6. Diabetes. 2016 Jan;65(1):140-8 - PubMed
  7. J Exp Med. 2014 Nov 17;211(12):2373-83 - PubMed
  8. J Endocrinol. 2014 Jan 08;220(2):T1-T23 - PubMed
  9. Blood. 2003 Feb 1;101(3):1155-63 - PubMed
  10. Circ Res. 2016 Feb 5;118(3):410-9 - PubMed
  11. Mol Cell Biol. 2004 Jun;24(12 ):5434-46 - PubMed
  12. Gene Expr. 2003;11(3-4):163-79 - PubMed
  13. Circ Res. 2016 Mar 4;118(5):810-21 - PubMed
  14. Cell Metab. 2015 Aug 4;22(2):279-90 - PubMed
  15. Nat Methods. 2012 Jun 28;9(7):676-82 - PubMed
  16. Cell Death Differ. 2012 May;19(5):891-9 - PubMed
  17. PLoS One. 2011 Mar 31;6(3):e17834 - PubMed
  18. Curr Protoc Immunol. 2008 Nov;Chapter 14:Unit 14.1 - PubMed
  19. Br J Cancer. 2008 Oct 21;99(8):1246-50 - PubMed
  20. Nutr Res Rev. 2015 Dec;28(2):121-132 - PubMed
  21. Immunity. 2014 Jul 17;41(1):36-48 - PubMed
  22. J Clin Invest. 2008 Jul;118(7):2640-50 - PubMed
  23. Diabetes. 2008 Jul;57(7):1790-9 - PubMed
  24. Diabetologia. 2016 Apr;59(4):679-82 - PubMed
  25. Biochim Biophys Acta. 2009 Feb;1792(2):83-92 - PubMed
  26. Am J Physiol Renal Physiol. 2013 Jul 1;305(1):F21-30 - PubMed
  27. Diabetes. 2012 May;61(5):1025-35 - PubMed
  28. Diabetes. 2010 Oct;59(10):2513-21 - PubMed
  29. Cancer Discov. 2012 Mar;2(3):236-47 - PubMed
  30. Diabetologia. 2016 May;59(5):879-94 - PubMed
  31. Biochem Soc Trans. 2012 Jun 1;40(3):539-45 - PubMed
  32. Rev Endocr Metab Disord. 2014 Dec;15(4):277-87 - PubMed
  33. Cardiovasc Res. 2004 Feb 1;61(2):297-306 - PubMed

Publication Types