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Xiao H, Tan C, Yang G, et al. The effect of red ginseng and ginseng leaves on the substance and energy metabolism in hypothyroidism rats. J Ginseng Res. 2017;41(4):556-565doi: 10.1016/j.jgr.2016.11.005.
Xiao, H., Tan, C., Yang, G., & Dou, D. (2017). The effect of red ginseng and ginseng leaves on the substance and energy metabolism in hypothyroidism rats. Journal of ginseng research, 41(4), 556-565. https://doi.org/10.1016/j.jgr.2016.11.005
Xiao, Hang, et al. "The effect of red ginseng and ginseng leaves on the substance and energy metabolism in hypothyroidism rats." Journal of ginseng research vol. 41,4 (2017): 556-565. doi: https://doi.org/10.1016/j.jgr.2016.11.005
Xiao H, Tan C, Yang G, Dou D. The effect of red ginseng and ginseng leaves on the substance and energy metabolism in hypothyroidism rats. J Ginseng Res. 2017 Oct;41(4):556-565. doi: 10.1016/j.jgr.2016.11.005. Epub 2017 Jan 16. PMID: 29021704; PMCID: PMC5628355.
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J Ginseng Res. 2017 Oct;41(4):556-565. doi: 10.1016/j.jgr.2016.11.005. Epub 2017 Jan 16.

The effect of red ginseng and ginseng leaves on the substance and energy metabolism in hypothyroidism rats.

Journal of ginseng research

Hang Xiao, Cheng Tan, Guanlin Yang, Deqiang Dou

Affiliations

  1. College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.
  2. The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China.

PMID: 29021704 PMCID: PMC5628355 DOI: 10.1016/j.jgr.2016.11.005

Abstract

BACKGROUND: Recent studies have revealed that the properties Traditional Chinese Medicine is mostly associated with are substance and energy metabolism. Our study aimed to compare the effect of red ginseng (RG) (warm property) and ginseng leaves (GL; cold property) on the substance and energy metabolism of rats with hypothyroidism.

MATERIALS AND METHODS: Rats were administered propylthiouracil intraperitoneally for 20 d to cause hypothyroidism. The reference group was orally administered Aconiti Lateralis Radix Praeparaia [FZ (Fuzi in Chinese)], while both the RG and GL groups were orally administrated crude drugs. The rectal, tail, toe, and axilla temperature of the rats were assayed every 3 d. Oxygen consumption, carbon dioxide production, heat production, and energy expenditure were measured via TSE phenoMaster/LabMaster animal monitoring system. Adenosine monophosphate-activated protein kinase, Na

RESULTS: The lower levels of triiodothyronine, tetraiodothyronine, and thyrotropin-releasing hormone and the higher level of thyroid stimulating hormone revealed the successful establishment of a hypothyroidism model. Oxygen consumption, carbon dioxide production, heat production, and energy expenditure in the FZ and RG groups were obviously increased. The activity of Na

CONCLUSION: Our research provides a new way to explore the efficiency of Chinese medicine on the basis of the relationship between drug property and effects on substance and energy metabolism.

Keywords: energy metabolism; ginseng; hypothyroidism; substance metabolism; the property of TCM

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