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Kaddoura I, Abu-Sittah G, Ibrahim A, et al. Burn injury: review of pathophysiology and therapeutic modalities in major burns. Ann Burns Fire Disasters. 2017;30(2):95-102
Kaddoura, I., Abu-Sittah, G., Ibrahim, A., Karamanoukian, R., & Papazian, N. (2017). Burn injury: review of pathophysiology and therapeutic modalities in major burns. Annals of burns and fire disasters, 30(2), 95-102.
Kaddoura, I, et al. "Burn injury: review of pathophysiology and therapeutic modalities in major burns." Annals of burns and fire disasters vol. 30,2 (2017): 95-102.
Kaddoura I, Abu-Sittah G, Ibrahim A, Karamanoukian R, Papazian N. Burn injury: review of pathophysiology and therapeutic modalities in major burns. Ann Burns Fire Disasters. 2017 Jun 30;30(2):95-102. PMID: 29021720; PMCID: PMC5627559.
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Ann Burns Fire Disasters. 2017 Jun 30;30(2):95-102.

Burn injury: review of pathophysiology and therapeutic modalities in major burns.

Annals of burns and fire disasters

I Kaddoura, G Abu-Sittah, A Ibrahim, R Karamanoukian, N Papazian

Affiliations

  1. Division of Plastic & Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon.
  2. Plastic & Reconstructive Surgery, Kare Plastic Surgery & Skin Health Center, Santa Monica, California, USA.

PMID: 29021720 PMCID: PMC5627559

Abstract

Despite a considerable decrease in their incidence worldwide, burn injuries remain one of the commonest forms of trauma and account for a weighty proportion of trauma cases in health-care emergencies around the globe. Although the latest data reveal a substantial decline in burn-related mortality and hospital admissions in the US over the past three decades, severe thermal injuries continue to trigger devastating morbidity and significant mortality while their management remains a dynamic challenge for the entire medical and paramedical community. Concrete evidence continues to be established regarding burn-associated pathophysiologic responses, and their destructive sequelae and deleterious effects in survivors at cellular, systemic as well as socio-economic level. Better understanding of these responses have contributed to advances in therapeutic strategies, improved long-term outcomes and catalyzed the reintegration of victims back into society. This paper describes the current understanding of the pathophysiology of a burn injury and characterizes both local and systemic pathophysiologic responses in terms of metabolic, hemodynamics, cardiac, renal, hepatic, gastro-intestinal, immunologic, endocrine as well as male reproductive systems in an attempt to understand the corresponding treatment modalities for this unique patient population.

Keywords: burn injury; major burns; modulators; pathophysiology

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