Display options
Cite
Cicero AFG, Fogacci F, Rosticci M, et al. Effect of a short-term dietary supplementation with phytosterols, red yeast rice or both on lipid pattern in moderately hypercholesterolemic subjects: a three-arm, double-blind, randomized clinical trial. Nutr Metab (Lond). 2017;14:61doi: 10.1186/s12986-017-0214-2.
Cicero, A. F. G., Fogacci, F., Rosticci, M., Parini, A., Giovannini, M., Veronesi, M., D'Addato, S., & Borghi, C. (2017). Effect of a short-term dietary supplementation with phytosterols, red yeast rice or both on lipid pattern in moderately hypercholesterolemic subjects: a three-arm, double-blind, randomized clinical trial. Nutrition & metabolism, 1461. https://doi.org/10.1186/s12986-017-0214-2
Cicero, Arrigo F G, et al. "Effect of a short-term dietary supplementation with phytosterols, red yeast rice or both on lipid pattern in moderately hypercholesterolemic subjects: a three-arm, double-blind, randomized clinical trial." Nutrition & metabolism vol. 14 (2017): 61. doi: https://doi.org/10.1186/s12986-017-0214-2
Cicero AFG, Fogacci F, Rosticci M, Parini A, Giovannini M, Veronesi M, D'Addato S, Borghi C. Effect of a short-term dietary supplementation with phytosterols, red yeast rice or both on lipid pattern in moderately hypercholesterolemic subjects: a three-arm, double-blind, randomized clinical trial. Nutr Metab (Lond). 2017 Sep 25;14:61. doi: 10.1186/s12986-017-0214-2. eCollection 2017. PMID: 29021813; PMCID: PMC5613479.
Copy Download .nbib Format: NLM
Share it on

Nutr Metab (Lond). 2017 Sep 25;14:61. doi: 10.1186/s12986-017-0214-2. eCollection 2017.

Effect of a short-term dietary supplementation with phytosterols, red yeast rice or both on lipid pattern in moderately hypercholesterolemic subjects: a three-arm, double-blind, randomized clinical trial.

Nutrition & metabolism

Arrigo F G Cicero, Federica Fogacci, Martina Rosticci, Angelo Parini, Marina Giovannini, Maddalena Veronesi, Sergio D'Addato, Claudio Borghi

Affiliations

  1. Medical and Surgical Sciences Department, University of Bologna, Via Albertoni 15, 40138 Bologna, Italy.

PMID: 29021813 PMCID: PMC5613479 DOI: 10.1186/s12986-017-0214-2

Abstract

BACKGROUND: Phytosterols and red yeast rice are largely studied cholesterol-lowering nutraceuticals, respectively inhibiting the bowel absorption and liver synthesis of cholesterol. Our aim was to test the effect on lipid profile of phytosterols, red yeast rice and their association.

METHODS: We performed a three parallel arms, double blind, clinical trial randomizing 90 moderately hypercholesterolemic subjects to treatment with phytosterols 800 mg (group 1), red yeast rice standardized to contain 5 mg monacolins from

RESULTS: After 8 weeks of treatment, in group 1 no significant variation of lipid parameters has been detected. In group 2 a significant reduction (

CONCLUSION: The association of phytosterol and red yeast rice seems to have additive cholesterol lowering effect, reaching a clinically significant LDL-Cholesterol reduction in mildly hypercholesterolemic patients.

TRIAL REGISTRATION: ClinicalTrial.gov ID: NCT02603276, Registered 27/08/2015.

Keywords: Clinical trial; LDL-cholesterol; Monacolins; Nutraceuticals; Phytosterols; Red yeast Rice

References

  1. Am J Cardiol. 2010 Jan 15;105(2):198-204 - PubMed
  2. PLoS One. 2012;7(3):e32736 - PubMed
  3. J Med Food. 2015 Nov;18(11):1270-3 - PubMed
  4. Nutr Metab Cardiovasc Dis. 2009 Feb;19(2):84-90 - PubMed
  5. Crit Rev Food Sci Nutr. 2014;54(9):1180-201 - PubMed
  6. J Nutr. 2009 Feb;139(2):271-84 - PubMed
  7. Am J Clin Nutr. 2008 Apr;87(4):993-1001 - PubMed
  8. Am Heart J. 2013 Jul;166(1):187-96 - PubMed
  9. Atherosclerosis. 2016 Oct;253:281-344 - PubMed
  10. Lancet. 2010 Nov 13;376(9753):1670-81 - PubMed
  11. J Agric Food Chem. 2000 Nov;48(11):5220-5 - PubMed
  12. J Food Sci Technol. 2012 Apr;49(2):173-83 - PubMed
  13. Atherosclerosis. 2014 Feb;232(2):346-60 - PubMed
  14. Nutr Res. 2013 Aug;33(8):622-8 - PubMed
  15. BMJ. 2000 Mar 25;320(7238):861-4 - PubMed
  16. Lipids. 2009 Dec;44(12):1141-8 - PubMed
  17. Food Funct. 2017 Jun 21;8(6):2076-2088 - PubMed
  18. Nutr Metab Cardiovasc Dis. 2017 Jan;27(1):2-17 - PubMed
  19. J Nutr. 2009 Jun;139(6):1143-9 - PubMed
  20. Am J Med. 2000 Jul;109(1):72-3 - PubMed
  21. Asia Pac J Clin Nutr. 2009;18(2):179-86 - PubMed
  22. Ann Nutr Metab. 2016;68(3):213-9 - PubMed
  23. Nutr J. 2015 Mar 28;14:30 - PubMed
  24. Am J Clin Nutr. 1999 Feb;69(2):231-6 - PubMed
  25. Eur J Clin Nutr. 2004 Oct;58(10 ):1378-85 - PubMed
  26. Eur J Intern Med. 2014 Sep;25(7):592-9 - PubMed
  27. Am J Cardiol. 2000 Jul 1;86(1):46-52 - PubMed
  28. Circulation. 2001 Feb 27;103(8):1177-9 - PubMed
  29. Phytomedicine. 2016 Oct 15;23 (11):1113-8 - PubMed
  30. Prostaglandins Leukot Essent Fatty Acids. 2011 Jul;85(1):9-28 - PubMed
  31. Ann Intern Med. 2009 Jun 16;150(12):830-9, W147-9 - PubMed

Publication Types