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Hull CM, Warrilow AGS, Rolley NJ, et al. Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases. Biotechnol Biofuels. 2017;10:226doi: 10.1186/s13068-017-0904-z.
Hull, C. M., Warrilow, A. G. S., Rolley, N. J., Price, C. L., Donnison, I. S., Kelly, D. E., & Kelly, S. L. (2017). Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases. Biotechnology for biofuels, 10226. https://doi.org/10.1186/s13068-017-0904-z
Hull, Claire M, et al. "Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases." Biotechnology for biofuels vol. 10 (2017): 226. doi: https://doi.org/10.1186/s13068-017-0904-z
Hull CM, Warrilow AGS, Rolley NJ, Price CL, Donnison IS, Kelly DE, Kelly SL. Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases. Biotechnol Biofuels. 2017 Sep 29;10:226. doi: 10.1186/s13068-017-0904-z. eCollection 2017. PMID: 29021826; PMCID: PMC5622474.
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Biotechnol Biofuels. 2017 Sep 29;10:226. doi: 10.1186/s13068-017-0904-z. eCollection 2017.

Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases.

Biotechnology for biofuels

Claire M Hull, Andrew G S Warrilow, Nicola J Rolley, Claire L Price, Iain S Donnison, Diane E Kelly, Steven L Kelly

Affiliations

  1. Institute of Life Science, Swansea University Medical School, Swansea, SA2 8PP Wales UK.
  2. Institute of Biological, Environmental & Rural Sciences, Aberystwyth University, Gogerddan, Aberystwyth, Wales SY23 3EE UK.

PMID: 29021826 PMCID: PMC5622474 DOI: 10.1186/s13068-017-0904-z

Abstract

BACKGROUND: Bioethanol production from sustainable sources of biomass that limit effect on food production are needed and in a biorefinery approach co-products are desirable, obtained from both the plant material and from the microbial biomass. Fungal biotransformation of steroids was among the first industrial biotransformations allowing corticosteroid production. In this work, the potential of yeast to produce intermediates needed in corticosteroid production is demonstrated at laboratory scale following bioethanol production from perennial ryegrass juice.

RESULTS: Genes encoding the 11α-steroid hydroxylase enzymes from

CONCLUSIONS: The progesterone 11α-steroid hydroxylases from

Keywords: 11α-Hydroxyprogesterone; Bioconversion; Bioethanol; Biorefinery; Ryegrass; Yeast

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