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Schmidt K, Bhakdisongkhram S, Uhle F, et al. Data on microcirculatory parameters of GTS- 21 treated rats assessed by intravital microscopy. Data Brief. 2017;15:228-233doi: 10.1016/j.dib.2017.09.045.
Schmidt, K., Bhakdisongkhram, S., Uhle, F., Philipsenburg, C., Zivkovic, A. R., Brenner, T., Motsch, J., Weigand, M. A., & Hofer, S. (2017). Data on microcirculatory parameters of GTS- 21 treated rats assessed by intravital microscopy. Data in brief, 15228-233. https://doi.org/10.1016/j.dib.2017.09.045
Schmidt, Karsten, et al. "Data on microcirculatory parameters of GTS- 21 treated rats assessed by intravital microscopy." Data in brief vol. 15 (2017): 228-233. doi: https://doi.org/10.1016/j.dib.2017.09.045
Schmidt K, Bhakdisongkhram S, Uhle F, Philipsenburg C, Zivkovic AR, Brenner T, Motsch J, Weigand MA, Hofer S. Data on microcirculatory parameters of GTS- 21 treated rats assessed by intravital microscopy. Data Brief. 2017 Sep 23;15:228-233. doi: 10.1016/j.dib.2017.09.045. eCollection 2017 Dec. PMID: 29022002; PMCID: PMC5633251.
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Data Brief. 2017 Sep 23;15:228-233. doi: 10.1016/j.dib.2017.09.045. eCollection 2017 Dec.

Data on microcirculatory parameters of GTS- 21 treated rats assessed by intravital microscopy.

Data in brief

Karsten Schmidt, Sukanya Bhakdisongkhram, Florian Uhle, Christoph Philipsenburg, Aleksandar R Zivkovic, Thorsten Brenner, Johann Motsch, Markus A Weigand, Stefan Hofer

Affiliations

  1. Department of Anesthesiology, Heidelberg University Hospital, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
  2. Clinic for Anesthesiology, Intensive Care and Emergency Medicine I, Westpfalz Hospital, Hellmut-Hartert-Str. 1, 67655 Kaiserslautern, Germany.

PMID: 29022002 PMCID: PMC5633251 DOI: 10.1016/j.dib.2017.09.045

Abstract

This article contains animal experimental data associated with the research article entitled "GTS-21 reduces microvascular permeability during experimental endotoxemia" (Schmidt et al., 2017) [1] (supplementary datasets of baseline intravital microscopic measurements, baseline TNF-α levels and vital parameters of the evaluated experimental groups are provided). Beneficial anti-inflammatory effects of cholinergic mediators on microvascular inflammation have been demonstrated by intravital microscopic investigations (Schmidt et al., 2015) [2], therefore we evaluated the effect of the cholinergic mediator GTS-21 on microcirculatory alterations during endotoxemia [1]. The data regarding microcirculatory effects of GTS-21 treatment ((3-(2,4-Dimethoxybenzylidene)-anabaseine dihydrochloride; 1 mg/kg; i.v.) in non-endotoxemic animals are presented in this article.

References

  1. BMC Anesthesiol. 2015 Aug 01;15:114 - PubMed
  2. Microvasc Res. 2018 Jan;115:75-82 - PubMed

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