Display options
Share it on

Front Neurosci. 2017 Sep 25;11:529. doi: 10.3389/fnins.2017.00529. eCollection 2017.

Type 1 Diabetes and Impaired Awareness of Hypoglycemia Are Associated with Reduced Brain Gray Matter Volumes.

Frontiers in neuroscience

Petr Bednarik, Amir A Moheet, Heidi Grohn, Anjali F Kumar, Lynn E Eberly, Elizabeth R Seaquist, Silvia Mangia

Affiliations

  1. Department of Radiology, Center for Magnetic Resonance Research, University of MinnesotaMinneapolis, MN, United States.
  2. Department of Medicine, University of MinnesotaMinneapolis, MN, United States.
  3. Division of Biostatistics, University of MinnesotaMinneapolis, MN, United States.

PMID: 28993722 PMCID: PMC5622182 DOI: 10.3389/fnins.2017.00529

Abstract

In this study, we retrospectively analyzed the anatomical MRI data acquired from 52 subjects with type 1 diabetes (26M/26F, 36 ± 11 years old, A1C = 7.2 ± 0.9%) and 50 age, sex and BMI frequency-matched non-diabetic controls (25M/25F, 36 ± 14 years old). The T1D group was further sub-divided based on whether subjects had normal, impaired, or indeterminate awareness of hypoglycemia (

Keywords: brain volumes; hypoglycemia; hypoglycemia unawareness; structural MRI; type 1 diabetes

References

  1. Annu Rev Neurosci. 2004;27:279-306 - PubMed
  2. Neuroimage. 2013 Oct 15;80:105-24 - PubMed
  3. Diabetes. 2006 Feb;55(2):326-33 - PubMed
  4. Neuron. 2002 Jan 31;33(3):341-55 - PubMed
  5. J Neurol Neurosurg Psychiatry. 1957 Feb;20(1):11-21 - PubMed
  6. Diabetologia. 2006 Oct;49(10):2474-80 - PubMed
  7. Neuron. 2002 Aug 15;35(4):625-41 - PubMed
  8. J Diabetes Complications. 2015 Nov-Dec;29(8):1277-82 - PubMed
  9. Brain Res. 2009 Jul 14;1280:186-94 - PubMed
  10. Ann N Y Acad Sci. 2015 Sep;1353:60-71 - PubMed
  11. Ann N Y Acad Sci. 2010 Nov;1212:12-28 - PubMed
  12. Diabet Med. 2006 Jan;23(1):32-9 - PubMed
  13. Brain. 2014 Jan;137(Pt 1):12-32 - PubMed
  14. Lancet. 2001 Apr 21;357(9264):1248-53 - PubMed
  15. Diabetes Care. 2004 May;27(5):1047-53 - PubMed
  16. Diabet Med. 2008 Apr;25(4):501-4 - PubMed
  17. Neuroimage. 2006 Jul 1;31(3):968-80 - PubMed
  18. Diabetes Metab Res Rev. 2014 Jul;30(5):341-5 - PubMed
  19. Diabet Med. 2007 Mar;24(3):327; author reply 328 - PubMed
  20. Diabetes Care. 1995 Apr;18(4):517-22 - PubMed
  21. Diabetes. 2005 Dec;54(12):3592-601 - PubMed
  22. Endocr Rev. 2008 Jun;29(4):494-511 - PubMed
  23. Curr Opin Neurol. 2006 Dec;19(6):586-92 - PubMed
  24. J Cereb Blood Flow Metab. 2012 Nov;32(11):2084-90 - PubMed
  25. Diabetes Care. 1994 Jul;17(7):697-703 - PubMed
  26. Diabetologia. 2003 Dec;46(12):1604-10 - PubMed
  27. Diabet Med. 2001 Sep;18(9):690-705 - PubMed
  28. Diabetologia. 1994 Dec;37(12):1265-76 - PubMed
  29. Diabetes. 1994 Dec;43(12):1426-34 - PubMed
  30. Neuroimage. 2004 Oct;23(2):724-38 - PubMed
  31. Diabetes Care. 2013 Dec;36(12):4063-70 - PubMed
  32. Diabetes Care. 2006 Nov;29(11):2539-48 - PubMed
  33. J Diabetes Complications. 2013 Nov-Dec;27(6):558-64 - PubMed
  34. J Cereb Blood Flow Metab. 2014 May;34(5):876-82 - PubMed
  35. Diabetes Care. 2017 Jan;40(Suppl 1):S4-S5 - PubMed
  36. Diabetes. 2010 Jan;59(1):236-41 - PubMed
  37. Diabetologia. 2007 Aug;50(8):1763-9 - PubMed

Publication Types

Grant support