Display options
Cite
Kim JN, Han SN, Ha TJ, et al. Black soybean anthocyanins attenuate inflammatory responses by suppressing reactive oxygen species production and mitogen activated protein kinases signaling in lipopolysaccharide-stimulated macrophages. Nutr Res Pract. 2017;11(5):357-364doi: 10.4162/nrp.2017.11.5.357.
Kim, J. N., Han, S. N., Ha, T. J., & Kim, H. K. (2017). Black soybean anthocyanins attenuate inflammatory responses by suppressing reactive oxygen species production and mitogen activated protein kinases signaling in lipopolysaccharide-stimulated macrophages. Nutrition research and practice, 11(5), 357-364. https://doi.org/10.4162/nrp.2017.11.5.357
Kim, Jin Nam, et al. "Black soybean anthocyanins attenuate inflammatory responses by suppressing reactive oxygen species production and mitogen activated protein kinases signaling in lipopolysaccharide-stimulated macrophages." Nutrition research and practice vol. 11,5 (2017): 357-364. doi: https://doi.org/10.4162/nrp.2017.11.5.357
Kim JN, Han SN, Ha TJ, Kim HK. Black soybean anthocyanins attenuate inflammatory responses by suppressing reactive oxygen species production and mitogen activated protein kinases signaling in lipopolysaccharide-stimulated macrophages. Nutr Res Pract. 2017 Oct;11(5):357-364. doi: 10.4162/nrp.2017.11.5.357. Epub 2017 Sep 18. PMID: 28989571; PMCID: PMC5621357.
Copy Download .nbib Format: NLM
Share it on

Nutr Res Pract. 2017 Oct;11(5):357-364. doi: 10.4162/nrp.2017.11.5.357. Epub 2017 Sep 18.

Black soybean anthocyanins attenuate inflammatory responses by suppressing reactive oxygen species production and mitogen activated protein kinases signaling in lipopolysaccharide-stimulated macrophages.

Nutrition research and practice

Jin Nam Kim, Sung Nim Han, Tae Joung Ha, Hye-Kyeong Kim

Affiliations

  1. Department of Food Science and Nutrition, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonngi 14662, Korea.
  2. Department of Food and Nutrition, Seoul National University, Seoul 08826, Korea.
  3. National Institute of Crop Science, Rural Development Administration (RDA), Wanju-gun, Jeonbuk 54875, Korea.

PMID: 28989571 PMCID: PMC5621357 DOI: 10.4162/nrp.2017.11.5.357

Abstract

BACKGROUND/OBJECTIVES: Oxidative stress is closely related with inflammation and development of many diseases. Black soybean seed coat contains high amount of anthocyanins, which are well-known for free radical scavenging activities. This study investigated inflammatory response and action mechanism of black soybean anthocyanins with regard to antioxidant activity in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.

MATERIALS/METHODS: RAW 264.7 cells were treated with anthocyanins extracted from black soybean seed coats in a concentration range of 12.5 to 100 µg/mL. The production of reactive oxygen species (ROS), secretion of pro-inflammatory mediators and cytokines, and the signaling in the mitogen activated protein kinases (MAPKs) pathway were examined.

RESULTS: Black soybean anthocyanins significantly decreased LPS-stimulated production of ROS, inflammatory mediators such as nitric oxide (NO) and prostaglandin E

CONCLUSION: These results suggest that black soybean anthocyanins exert anti-inflammatory activity by inhibiting ROS generation and subsequent MAPKs signaling, thereby inhibiting inflammatory responses.

Keywords: Anthocyanins; anti-inflammatory agents; macrophage; mitogen-activated protein kinases; reactive oxygen species

Conflict of interest statement

CONFLICT OF INTEREST: The authors declare no potential conflicts of interests.

References

  1. Science. 2002 Dec 6;298(5600):1911-2 - PubMed
  2. Biochem Biophys Res Commun. 1994 Oct 28;204(2):635-40 - PubMed
  3. Springerplus. 2013 Dec 21;2:686 - PubMed
  4. Int Immunopharmacol. 2010 Aug;10 (8):959-66 - PubMed
  5. Plant Foods Hum Nutr. 2010 Sep;65(3):266-70 - PubMed
  6. Microsurgery. 2012 Oct;32(7):563-70 - PubMed
  7. Biochem J. 2007 Mar 1;402(2):271-8 - PubMed
  8. J Physiol Pharmacol. 2003 Dec;54(4):469-87 - PubMed
  9. Arch Biochem Biophys. 2006 Mar 15;447(2):136-46 - PubMed
  10. BMC Neurosci. 2011 May 26;12:49 - PubMed
  11. J Agric Food Chem. 2001 Dec;49(12):5848-51 - PubMed
  12. J Agric Food Chem. 2007 Nov 14;55(23):9427-35 - PubMed
  13. Gut. 1998 Jun;42(6):768-71 - PubMed
  14. Glia. 2003 Jan 15;41(2):152-60 - PubMed
  15. Free Radic Biol Med. 2010 Dec 1;49(11):1603-16 - PubMed
  16. Curr Eye Res. 2014 Nov;39(11):1090-8 - PubMed
  17. Int J Mol Sci. 2013 Jan 14;14(1):1502-15 - PubMed
  18. Cell Res. 2005 Jan;15(1):24-7 - PubMed
  19. Cell. 2005 Mar 11;120(5):649-61 - PubMed
  20. J Immunol. 1983 Apr;130(4):1910-7 - PubMed
  21. J Immunol. 2012 Jan 1;188(1):21-8 - PubMed
  22. Free Radic Biol Med. 2010 Dec 15;49(12 ):1978-88 - PubMed
  23. Nat Immunol. 2005 Jun;6(6):587-92 - PubMed
  24. J Agric Food Chem. 2011 Jun 8;59(11):5935-44 - PubMed
  25. J Agric Food Chem. 2008 Oct 8;56(19):8969-74 - PubMed
  26. Curr Drug Targets Inflamm Allergy. 2005 Jun;4(3):281-6 - PubMed
  27. Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2576-81 - PubMed
  28. Immunopharmacol Immunotoxicol. 2015 Jun;37(3):228-35 - PubMed
  29. Urology. 2014 Nov;84(5):1112-6 - PubMed
  30. Front Physiol. 2014 Sep 29;5:352 - PubMed
  31. Microbiol Immunol. 2013 May;57(5):366-73 - PubMed
  32. J Agric Food Chem. 2006 May 31;54(11):4069-75 - PubMed
  33. Biochem Pharmacol. 2005 Mar 1;69(5):791-9 - PubMed
  34. J Exp Med. 2011 Mar 14;208(3):519-33 - PubMed

Publication Types