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J Microbio Robot. 2016;11(1):1-18. doi: 10.1007/s12213-016-0087-x. Epub 2016 May 02.

Frontiers of robotic endoscopic capsules: a review.

Journal of micro-bio robotics

Gastone Ciuti, R Caliò, D Camboni, L Neri, F Bianchi, A Arezzo, A Koulaouzidis, S Schostek, D Stoyanov, C M Oddo, B Magnani, A Menciassi, M Morino, M O Schurr, P Dario

Affiliations

  1. The BioRobotics Institute of Scuola Superiore Sant'Anna, Pontedera, Pisa 56025 Italy.
  2. Ekymed S.r.l., Livorno, Italy.
  3. Department of Surgical Disciplines, University of Torino, Torino, Italy.
  4. Endoscopy Unit, The Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK.
  5. Ovesco Endoscopy AG, Tübingen, Germany.
  6. Centre for Medical Image Computing and the Department of Computer Science, University College London, London, UK.
  7. Steinbeis University Berlin, Berlin, Germany.

PMID: 29082124 PMCID: PMC5646258 DOI: 10.1007/s12213-016-0087-x

Abstract

Digestive diseases are a major burden for society and healthcare systems, and with an aging population, the importance of their effective management will become critical. Healthcare systems worldwide already struggle to insure quality and affordability of healthcare delivery and this will be a significant challenge in the midterm future. Wireless capsule endoscopy (WCE), introduced in 2000 by Given Imaging Ltd., is an example of disruptive technology and represents an attractive alternative to traditional diagnostic techniques. WCE overcomes conventional endoscopy enabling inspection of the digestive system without discomfort or the need for sedation. Thus, it has the advantage of encouraging patients to undergo gastrointestinal (GI) tract examinations and of facilitating mass screening programmes. With the integration of further capabilities based on microrobotics, e.g. active locomotion and embedded therapeutic modules, WCE could become the key-technology for GI diagnosis and treatment. This review presents a research update on WCE and describes the state-of-the-art of current endoscopic devices with a focus on research-oriented robotic capsule endoscopes enabled by microsystem technologies. The article also presents a visionary perspective on WCE potential for screening, diagnostic and therapeutic endoscopic procedures.

Keywords: Digestive endoscopy; Medical robots; Microsystem technologies; Robotic endoscopic capsules; Wireless capsule endoscopy (WCE)

References

  1. Gastrointest Endosc. 2011 Jan;73(1):22-8 - PubMed
  2. Endoscopy. 2016 Mar;48(3):286-90 - PubMed
  3. Hong Kong Med J. 2016 Feb;22(1):70-7 - PubMed
  4. Ann Gastroenterol. 2013;26(4):365-367 - PubMed
  5. Tech Gastrointest Endosc. 2015 Jan 1;17(1):40-46 - PubMed
  6. Gastrointest Endosc. 2014 Oct;80(4):642-51 - PubMed
  7. World J Gastrointest Endosc. 2014 Jun 16;6(6):227-33 - PubMed
  8. IEEE Trans Biomed Eng. 2014 Mar;61(3):794-804 - PubMed
  9. Clin Gastroenterol Hepatol. 2006 Aug;4(8):979-87 - PubMed
  10. J R Coll Physicians Edinb. 2011 Jun;41(2):124-5 - PubMed
  11. Gastrointest Endosc. 2008 Sep;68(3):528-30 - PubMed
  12. Nat Rev Gastroenterol Hepatol. 2012 May 08;9(7):392-405 - PubMed
  13. J Gastroenterol Hepatol. 2014 May;29(5):992-6 - PubMed
  14. IEEE Trans Biomed Eng. 2012 Apr;59(4):1005-11 - PubMed
  15. Sensors (Basel). 2015 Apr 03;15(4):8020-41 - PubMed
  16. IEEE Trans Biomed Eng. 2007 Dec;54(12):2231-6 - PubMed
  17. IEEE Trans Neural Syst Rehabil Eng. 2007 Sep;15(3):469-71 - PubMed
  18. World J Gastrointest Endosc. 2012 Mar 16;4(3):57-64 - PubMed
  19. Endoscopy. 2008 Dec;40(12):979-82 - PubMed
  20. IEEE Trans Neural Netw Learn Syst. 2017 Apr;28(4):819-829 - PubMed
  21. Gastrointest Endosc. 2008 Jun;67(7):1153-8 - PubMed
  22. IEEE Trans Biomed Eng. 1994 Feb;41(2):192-5 - PubMed
  23. Neurogastroenterol Motil. 2011 Jan;23(1):8-23 - PubMed
  24. IEEE Trans Robot. 2016 Apr;32(2):327-338 - PubMed
  25. Gastrointest Endosc. 2013 Dec;78(6):805-15 - PubMed
  26. Endoscopy. 2010 Dec;42(12 ):1108-11 - PubMed
  27. Minim Invasive Ther Allied Technol. 2009;18(5):280-90 - PubMed
  28. IEEE Pulse. 2010 Nov-Dec;1(3):26-41 - PubMed
  29. IEEE Trans Biomed Eng. 2014 Feb;61(2):513-21 - PubMed
  30. Biosensors (Basel). 2014 Nov 03;4(4):422-48 - PubMed
  31. Cancer Epidemiol. 2015 Dec;39 Suppl 1:S139-52 - PubMed
  32. Minim Invasive Ther Allied Technol. 2015 Feb;24(1):37-44 - PubMed
  33. IEEE Trans Biomed Eng. 2009 May;56(5):1482-90 - PubMed
  34. IEEE Trans Biomed Eng. 2004 Mar;51(3):525-35 - PubMed
  35. World J Gastroenterol. 2015 Oct 7;21(37):10528-41 - PubMed
  36. Surg Endosc. 2012 Oct;26(10):2862-9 - PubMed
  37. Biosens Bioelectron. 2016 Apr 15;78:524-9 - PubMed
  38. J Clin Gastroenterol. 2012 Mar;46(3):197-200 - PubMed
  39. IEEE Trans Biomed Circuits Syst. 2010 Dec;4(6):462-8 - PubMed
  40. IEEE Trans Biomed Eng. 2013 Jan;60(1):55-62 - PubMed
  41. Am J Robot Surg. 2014 Jun;1(1):48-54 - PubMed
  42. Dig Endosc. 2015 Jan;27(2):223-31 - PubMed
  43. Sci Transl Med. 2014 Feb 5;6(222):222ra19 - PubMed
  44. IEEE Trans Biomed Eng. 2015 May;62(5):1324-32 - PubMed
  45. J Med Eng Technol. 2009;33(3):192-8 - PubMed
  46. Expert Rev Gastroenterol Hepatol. 2015 Feb;9(2):217-35 - PubMed
  47. Dig Endosc. 2015 Jan;27(2):205-15 - PubMed
  48. Gastrointest Endosc. 2001 Jul;54(1):79-83 - PubMed
  49. IEEE Rev Biomed Eng. 2011;4:59-72 - PubMed
  50. Aliment Pharmacol Ther. 2012 Nov;36(10):929-40 - PubMed
  51. Med Phys. 2011 Jun;38(6):3077-89 - PubMed
  52. Conf Proc IEEE Eng Med Biol Soc. 2015;2015:2263-6 - PubMed
  53. IEEE Trans Biomed Eng. 2013 Apr;60(4):945-53 - PubMed
  54. Phys Med Biol. 2008 Aug 21;53(16):4355-68 - PubMed
  55. Endoscopy. 2015 Aug;47(8):719-25 - PubMed
  56. Surg Endosc. 2012 May;26(5):1238-46 - PubMed
  57. IEEE Trans Med Imaging. 2014 Jul;33(7):1488-502 - PubMed
  58. Comput Math Methods Med. 2015;2015:607407 - PubMed
  59. Biomed Microdevices. 2012 Feb;14(1):165-78 - PubMed
  60. World J Gastroenterol. 2011 Oct 14;17 (38):4308-13 - PubMed
  61. Conf Proc IEEE Eng Med Biol Soc. 2014;2014:6977-80 - PubMed
  62. IEEE Trans Med Imaging. 2011 Apr;30(4):957-71 - PubMed
  63. Gastrointest Endosc. 2009 Jan;69(1):124-35 - PubMed
  64. Adv Drug Deliv Rev. 2014 May;71:77-85 - PubMed
  65. Dig Liver Dis. 2013 Aug;45(8):657-62 - PubMed
  66. World J Gastroenterol. 2013 Jun 28;19(24):3726-46 - PubMed
  67. Pharm Sci Technolo Today. 2000 Nov 1;3(11):385-392 - PubMed
  68. Sci Transl Med. 2014 Oct 8;6(257):257re6 - PubMed
  69. Gastrointest Endosc. 2009 Oct;70(4):645-54 - PubMed
  70. Gastrointest Endosc. 2005 May;61(6):679-85 - PubMed
  71. Endoscopy. 2010 Feb;42(2):148-52 - PubMed
  72. J Pharm Sci. 1997 Nov;86(11):1218-22 - PubMed
  73. Minim Invasive Ther Allied Technol. 2006;15(5):296-304 - PubMed
  74. IEEE Trans Biomed Circuits Syst. 2010 Aug;4(4):239-49 - PubMed
  75. Gastrointest Endosc. 2009 Feb;69(2):253-9 - PubMed
  76. J Clin Gastroenterol. 2014 Jan;48(1):52-4 - PubMed
  77. IEEE Trans Biomed Eng. 2012 Sep;59(9):2387-99 - PubMed
  78. Nat Rev Gastroenterol Hepatol. 2015 Mar;12(3):172-86 - PubMed
  79. Clin Gastroenterol Hepatol. 2015 Dec;13(13):2302-4 - PubMed
  80. Magn Reson Med. 1993 Mar;29(3):411-5 - PubMed
  81. World J Gastroenterol. 2015 May 7;21(17):5119-30 - PubMed
  82. Physiol Behav. 2014 Apr 10;128:180-7 - PubMed
  83. Elife. 2016 Mar 08;5:e09148 - PubMed
  84. Biomed Mater Eng. 2015;26 Suppl 1:S1721-30 - PubMed
  85. Gut. 2015 Jul;64(7):1158-77 - PubMed
  86. Int J Biometeorol. 2014 Jan;58(1):7-15 - PubMed
  87. IEEE Trans Biomed Eng. 2013 May;60(5):1225-33 - PubMed
  88. Sci Transl Med. 2014 Oct 8;6(257):257ra138 - PubMed
  89. Opt Express. 2015 Apr 6;23(7):8565-75 - PubMed
  90. Ind Rob. 2004 Dec;31(6):499-508 - PubMed
  91. Gastrointest Endosc Clin N Am. 2004 Jan;14(1):25-31 - PubMed
  92. Nature. 2000 May 25;405(6785):417 - PubMed
  93. World J Gastrointest Endosc. 2015 Jan 16;7(1):13-36 - PubMed
  94. Gastrointest Endosc. 2012 Feb;75(2):373-81 - PubMed
  95. IEEE Trans Biomed Eng. 2011 Feb;58(2):231-4 - PubMed
  96. Expert Rev Med Devices. 2014 Nov;11(6):649-66 - PubMed

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