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Deguchi H, Elias DJ, Griffin JH. Minor Plasma Lipids Modulate Clotting Factor Activities and May Affect Thrombosis Risk. Res Pract Thromb Haemost. 2017;1(1):93-102doi: 10.1002/rth2.12017.
Deguchi, H., Elias, D. J., & Griffin, J. H. (2017). Minor Plasma Lipids Modulate Clotting Factor Activities and May Affect Thrombosis Risk. Research and practice in thrombosis and haemostasis, 1(1), 93-102. https://doi.org/10.1002/rth2.12017
Deguchi, Hiroshi, et al. "Minor Plasma Lipids Modulate Clotting Factor Activities and May Affect Thrombosis Risk." Research and practice in thrombosis and haemostasis vol. 1,1 (2017): 93-102. doi: https://doi.org/10.1002/rth2.12017
Deguchi H, Elias DJ, Griffin JH. Minor Plasma Lipids Modulate Clotting Factor Activities and May Affect Thrombosis Risk. Res Pract Thromb Haemost. 2017 Jul;1(1):93-102. doi: 10.1002/rth2.12017. Epub 2017 Jun 20. PMID: 29082360; PMCID: PMC5658053.
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Res Pract Thromb Haemost. 2017 Jul;1(1):93-102. doi: 10.1002/rth2.12017. Epub 2017 Jun 20.

Minor Plasma Lipids Modulate Clotting Factor Activities and May Affect Thrombosis Risk.

Research and practice in thrombosis and haemostasis

Hiroshi Deguchi, Darlene J Elias, John H Griffin

Affiliations

  1. Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.
  2. Scripps Clinic and Scripps Green Hospital, La Jolla, CA, USA.
  3. Department of Medicine, University of California San Diego, La Jolla, CA, USA.

PMID: 29082360 PMCID: PMC5658053 DOI: 10.1002/rth2.12017

Abstract

Different minor abundance plasma lipids significantly influence thrombin generation in vitro and significant differences in such lipids are linked to risk for venous thrombosis. Some plasma sphingolipids including glucosylceramide, lyso-sulfatide and sphingosine have anticoagulant properties whereas, conversely, some plasma phospholipid derivatives, including certain lyso-phospholipids and ethanolamides, have procoagulant properties. Plasma metabolite profiling of venous thrombosis patients showed association of venous thrombosis with decreased plasma long-chain acylcarntines, leading to discovery of their anticoagulant activity as inhibitors of factor Xa. Inhibition of factor Xa by acylcarnitines does not require the protein's Gla-domain, emphasizing an expanded framework for the paradigm for lipid-clotting factor interactions. Overall, whether by genetics or environment, alterations in the dynamics of lipid metabolism linked to an altered lipidome may contribute to regulation of blood coagulation because imbalances between physiologic procoagulant and anticoagulant lipids may contribute to excessive thrombin generation that augments risk for thrombosis.

Keywords: Venous Thromboembolism; blood coagulation; lipids; phospholipids; sphingolipids; thrombin

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