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Liu X, Qi W, Wang Y, et al. A facile strategy for enzyme immobilization with highly stable hierarchically porous metal-organic frameworks. Nanoscale. 2017;9(44):17561-17570doi: 10.1039/c7nr06019j.
Liu, X., Qi, W., Wang, Y., Su, R., & He, Z. (2017). A facile strategy for enzyme immobilization with highly stable hierarchically porous metal-organic frameworks. Nanoscale, 9(44), 17561-17570. https://doi.org/10.1039/c7nr06019j
Liu, Xiao, et al. "A facile strategy for enzyme immobilization with highly stable hierarchically porous metal-organic frameworks." Nanoscale vol. 9,44 (2017): 17561-17570. doi: https://doi.org/10.1039/c7nr06019j
Liu X, Qi W, Wang Y, Su R, He Z. A facile strategy for enzyme immobilization with highly stable hierarchically porous metal-organic frameworks. Nanoscale. 2017 Nov 16;9(44):17561-17570. doi: 10.1039/c7nr06019j. PMID: 29112218.
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Nanoscale. 2017 Nov 16;9(44):17561-17570. doi: 10.1039/c7nr06019j.

A facile strategy for enzyme immobilization with highly stable hierarchically porous metal-organic frameworks.

Nanoscale

Xiao Liu, Wei Qi, Yuefei Wang, Rongxin Su, Zhimin He

Affiliations

  1. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China. [email protected] [email protected].
  2. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China. [email protected] [email protected] and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. China and Tianjin Key Laboratory of Membrane Science and Desalination Technology, Tianjin University, Tianjin 300072, P. R. China.
  3. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China. [email protected] [email protected] and Tianjin Key Laboratory of Membrane Science and Desalination Technology, Tianjin University, Tianjin 300072, P. R. China.

PMID: 29112218 DOI: 10.1039/c7nr06019j

Abstract

Metal-organic frameworks (MOFs) have drawn extensive research interest as candidates for enzyme immobilization owing to their tunable porosity, high surface area, and excellent chemical/thermal stability. Herein, we report a facile and universal strategy for enzyme immobilization using highly stable hierarchically porous metal-organic frameworks (HP-MOFs). The HP-MOFs were stable over a wide pH range (pH = 2-11 for HP-DUT-5) and met the catalysis conditions of most enzymes. The as-prepared hierarchical micro/mesoporous MOFs with mesoporous defects showed a superior adsorption capacity towards enzymes. The maximum adsorption capacity of HP-DUT-5 for glucose oxidase (GOx) and uricase was 208 mg g

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