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Forbes JA, Kolodny AL, Beaver WT, et al. A 12-Hour Evaluation of the Analgesic Efficacy of Diflunisal, Acetaminophen, an Acetaminophen-Codeine Combination, and Placebo in Postoperative Pain. Pharmacotherapy. 1983;3(2):47S-54Sdoi: 10.1002/phar.1983.3.2p2.47.
Forbes, J. A., Kolodny, A. L., Beaver, W. T., Shackleford, R. W., & Scarlett, V. R. (1983). A 12-Hour Evaluation of the Analgesic Efficacy of Diflunisal, Acetaminophen, an Acetaminophen-Codeine Combination, and Placebo in Postoperative Pain. Pharmacotherapy, 3(2), 47S-54S. https://doi.org/10.1002/phar.1983.3.2p2.47
Forbes, James A, et al. "A 12-Hour Evaluation of the Analgesic Efficacy of Diflunisal, Acetaminophen, an Acetaminophen-Codeine Combination, and Placebo in Postoperative Pain." Pharmacotherapy vol. 3,2 (1983): 47S-54S. doi: https://doi.org/10.1002/phar.1983.3.2p2.47
Forbes JA, Kolodny AL, Beaver WT, Shackleford RW, Scarlett VR. A 12-Hour Evaluation of the Analgesic Efficacy of Diflunisal, Acetaminophen, an Acetaminophen-Codeine Combination, and Placebo in Postoperative Pain. Pharmacotherapy. 1983 Mar;3(2):47S-54S. doi: 10.1002/phar.1983.3.2p2.47. PMID: 29112308.
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Pharmacotherapy. 1983 Mar;3(2):47S-54S. doi: 10.1002/phar.1983.3.2p2.47.

A 12-Hour Evaluation of the Analgesic Efficacy of Diflunisal, Acetaminophen, an Acetaminophen-Codeine Combination, and Placebo in Postoperative Pain.

Pharmacotherapy

James A Forbes, A Lewis Kolodny, William T Beaver, Robert W Shackleford, Virginia R Scarlett

Affiliations

  1. Department of Surgery, Franklin Square Hospital, Baltimore, and the Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore.
  2. Department of Rheumatology, Franklin Square Hospital, Baltimore.
  3. Departments of Pharmacology and Anesthesia, Georgetown University Schools of Medicine and Dentistry, Washington.
  4. Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania.

PMID: 29112308 DOI: 10.1002/phar.1983.3.2p2.47

Abstract

The analgesic efficacy of single 500 and 1,000 mg doses of diflunisal, a new nonsteroidal antiinflammatory analgesic, was compared in a double-blind study with acetaminophen 600 mg, the combination of acetaminophen 600 mg with codeine 60 mg, and placebo in 132 inpatients with postoperative pain. Using a self-rating record, patients rated their pain and its relief hourly for up to 12 hours after medication. Diflunisal 500 and 1,000 mg were significantly superior to placebo for every measure of total and peak analgesia, and a significant analgesic effect persisted for 8 hours. Acetaminophen alone and the acetaminophen-codeine combination were significantly superior to placebo for most measures of analgesia, and their effects were significant for 4 and 5 hours respectively. Differences among the active medications were not statistically significant for measures of total or peak analgesia.

1983 Pharmacotherapy Publications Inc.

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