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Olczak B, Kowalski G, Leppert W, et al. Analgesic efficacy and safety of epidural oxycodone in patients undergoing total hip arthroplasty: a pilot study. J Pain Res. 2017;10:2303-2309doi: 10.2147/JPR.S144799.
Olczak, B., Kowalski, G., Leppert, W., Bienert, A., Teżyk, A., Adamski, M., Rzymski, S., & Wieczorowska-Tobis, K. (2017). Analgesic efficacy and safety of epidural oxycodone in patients undergoing total hip arthroplasty: a pilot study. Journal of pain research, 102303-2309. https://doi.org/10.2147/JPR.S144799
Olczak, Bogumił, et al. "Analgesic efficacy and safety of epidural oxycodone in patients undergoing total hip arthroplasty: a pilot study." Journal of pain research vol. 10 (2017): 2303-2309. doi: https://doi.org/10.2147/JPR.S144799
Olczak B, Kowalski G, Leppert W, Bienert A, Teżyk A, Adamski M, Rzymski S, Wieczorowska-Tobis K. Analgesic efficacy and safety of epidural oxycodone in patients undergoing total hip arthroplasty: a pilot study. J Pain Res. 2017 Sep 27;10:2303-2309. doi: 10.2147/JPR.S144799. eCollection 2017. PMID: 29026333; PMCID: PMC5627752.
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J Pain Res. 2017 Sep 27;10:2303-2309. doi: 10.2147/JPR.S144799. eCollection 2017.

Analgesic efficacy and safety of epidural oxycodone in patients undergoing total hip arthroplasty: a pilot study.

Journal of pain research

Bogumił Olczak, Grzegorz Kowalski, Wojciech Leppert, Agnieszka Bienert, Artur Teżyk, Michał Adamski, Stanisław Rzymski, Katarzyna Wieczorowska-Tobis

Affiliations

  1. Department of Anaesthesiology, Józef Stru? Multiprofile Municipal Hospital, Pozna?.
  2. Department of Palliative Medicine.
  3. Department of Clinical Pharmacy and Biopharmacy.
  4. Department of Forensic Medicine, Poznan University of Medical Sciences, Pozna?, Poland.

PMID: 29026333 PMCID: PMC5627752 DOI: 10.2147/JPR.S144799

Abstract

BACKGROUND AND OBJECTIVES: Oxycodone is poorly studied as an adjuvant to central blockades. The aim of this pilot study was to assess the efficacy and safety of oxycodone hydrochloride in epidural blockade among patients undergoing total hip arthroplasty (THA).

PATIENTS AND METHODS: In 11 patients (American Society of Anesthesiologists physical status classification system II/III, age range: 59-82 years), THA was conducted with an epidural blockade using 15 mL 0.25% bupivacaine (37.5 mg) with 5 mg oxycodone hydrochloride and sedation with propofol infusion at a dose of 3-5 mg/kg/h. After the surgery, patients received ketoprofen at a dose of 100 mg twice daily. In the first 24 hours postoperative period, pain was assessed by numerical rating scale at rest and on movement; adverse effects (AEs) were recorded; and plasma concentrations of oxycodone, noroxycodone, and bupivacaine were measured.

RESULTS: The administration of epidural oxycodone at a dose of 5 mg in patients undergoing THA provided analgesia for a mean time of 10.3±4.89 h. In one patient, mild pruritus was observed. Oxycodone did not evoke other AEs. Plasma concentrations of oxycodone while preserving analgesia were >2.9 ng/mL. Noroxycodone concentrations in plasma did not guarantee analgesic effect.

CONCLUSION: The administration of epidural oxycodone at a dose of 5 mg prolongs the analgesia period to ~10 hours in patients after THA. Oxycodone may evoke pruritus. A 5 mg dose of oxycodone hydrochloride used in an epidural blockade seems to be a safe drug in patients after THA.

Keywords: analgesia; oxycodone; pain; total hip arthroplasty

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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