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Haddock JH, Mercante DE, Paccione R, et al. Use of Digital Pupillometry to Measure Sedative Response to Propofol. Ochsner J. 2017;17(3):250-253
Haddock, J. H., Mercante, D. E., Paccione, R., Breaux, J. L., Jolley, S. E., Johnson, J. L., Connolly, S. E., & deBoisblanc, B. P. (2017). Use of Digital Pupillometry to Measure Sedative Response to Propofol. The Ochsner journal, 17(3), 250-253.
Haddock, Jody H, et al. "Use of Digital Pupillometry to Measure Sedative Response to Propofol." The Ochsner journal vol. 17,3 (2017): 250-253.
Haddock JH, Mercante DE, Paccione R, Breaux JL, Jolley SE, Johnson JL, Connolly SE, deBoisblanc BP. Use of Digital Pupillometry to Measure Sedative Response to Propofol. Ochsner J. 2017;17(3):250-253. PMID: 29026357; PMCID: PMC5625983.
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Ochsner J. 2017;17(3):250-253.

Use of Digital Pupillometry to Measure Sedative Response to Propofol.

The Ochsner journal

Jody H Haddock, Donald E Mercante, Rose Paccione, Jacob L Breaux, Sarah E Jolley, Jessica L Johnson, Sean E Connolly, Bennett P deBoisblanc

Affiliations

  1. Section of Pulmonary/Critical Care and Allergy/Immunology, Louisiana State University School of Medicine, New Orleans, LA.
  2. Department of Biostatistics, Louisiana State University School of Medicine, New Orleans, LA.
  3. Department of Gastroenterology, Ochsner Clinic Foundation, New Orleans, LA.
  4. Xavier University of Louisiana College of Pharmacy, New Orleans, LA.

PMID: 29026357 PMCID: PMC5625983

Abstract

BACKGROUND: Digital pupillometry (DP) accurately and precisely measures pupillary responses. Little is known about using DP to measure the sedative effect of isolated propofol administration.

METHODS: We conducted a cross-sectional study of 19 adults undergoing moderate sedation with propofol during which we measured pupillary changes using DP.

RESULTS: Maximum and minimum pupillary diameters decreased significantly with propofol (mean change from baseline to procedural termination -1.24 mm, standard error [SE] 0.25 and -0.79 mm, SE 0.13, respectively;

CONCLUSION: We speculate that DP may be a useful tool to monitor propofol sedation.

Keywords: Conscious sedation; hypnotics and sedatives; propofol; reflex–pupillary

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