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Ordookhani A, Burman KD. Hemostasis in Hypothyroidism and Autoimmune Thyroid Disorders. Int J Endocrinol Metab. 2017;15(2):e42649doi: 10.5812/ijem.42649.
Ordookhani, A., & Burman, K. D. (2017). Hemostasis in Hypothyroidism and Autoimmune Thyroid Disorders. International journal of endocrinology and metabolism, 15(2), e42649. https://doi.org/10.5812/ijem.42649
Ordookhani, Arash, and Burman, Kenneth D. "Hemostasis in Hypothyroidism and Autoimmune Thyroid Disorders." International journal of endocrinology and metabolism vol. 15,2 (2017): e42649. doi: https://doi.org/10.5812/ijem.42649
Ordookhani A, Burman KD. Hemostasis in Hypothyroidism and Autoimmune Thyroid Disorders. Int J Endocrinol Metab. 2017 Mar 09;15(2):e42649. doi: 10.5812/ijem.42649. eCollection 2017 Apr. PMID: 29026409; PMCID: PMC5626118.
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Int J Endocrinol Metab. 2017 Mar 09;15(2):e42649. doi: 10.5812/ijem.42649. eCollection 2017 Apr.

Hemostasis in Hypothyroidism and Autoimmune Thyroid Disorders.

International journal of endocrinology and metabolism

Arash Ordookhani, Kenneth D Burman

Affiliations

  1. Endocrine Section, Department of Internal Medicine, Providence Hospital, Washington, DC, 20017.
  2. Endocrine Section, MedStar Washington Hospital Center, Washington, DC, 20010.

PMID: 29026409 PMCID: PMC5626118 DOI: 10.5812/ijem.42649

Abstract

CONTEXT: There are contradictory results on the effect of hypothyroidism on the changes in hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). This paper reviews the studies on laboratory and population-based findings regarding hemostatic changes and risk of VTE in hypothyroidism and autoimmune thyroid disorders.

EVIDENCE ACQUISITION: A comprehensive literature search was conducted employing MEDLINE database. The following words were used for the search: Hypothyroidism; thyroiditis, autoimmune; blood coagulation factors; blood coagulation tests; hemostasis, blood coagulation disorders; thyroid hormones; myxedema; venous thromboembolism; fibrinolysis, receptors thyroid hormone. The papers that were related to hypothyroidism and autoimmune thyroid disorder and hemostasis are used in this review.

RESULTS: Overt hypothyroidism is more associated with a hypocoagulable state. Decreased platelet count, aggregation and agglutination, von Willebrand factor antigen and activity, several coagulation factors such as factor VIII, IX, XI, VII, and plasminogen activator-1 are detected in overt hypothyrodism. Increased fibrinogen has been detected in subclinical hypothyroidism and autoimmune thyroid disease rendering a tendency towards a hypercoagulability state. Increased factor VII and its activity, and plasminogen activator inhibitor-1 are among several findings contributing to a prothrombotic state in subclinical hypothyroidism.

CONCLUSIONS: Overt hypothyroidism is associated with a hypocoagulable state and subclinical hypothyroidism and autoimmune thyroid disorders may induce a prothrombotic state. However, there are contradictory findings for the abovementioned thyroid disorders. Prospective studies on the risk of VTE in various levels of hypofunctioning of the thyroid and autoimmune thyroid disorders are warranted.

Keywords: Blood Coagulation Factors; Fibrinolysis; Hashimoto Disease; Hypothyroidism; Myxedema; Thyroiditis, Autoimmune; Venous Thromboembolism

Conflict of interest statement

Conflict of Interest:None to declare.

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