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Giuliano A, Dobson J, Mason S. Complete Resolution of a Recurrent Canine Anal Sac Squamous Cell Carcinoma with Palliative Radiotherapy and Carboplatin Chemotherapy. Vet Sci. 2017;4(3)doi: 10.3390/vetsci4030045.
Giuliano, A., Dobson, J., & Mason, S. (2017). Complete Resolution of a Recurrent Canine Anal Sac Squamous Cell Carcinoma with Palliative Radiotherapy and Carboplatin Chemotherapy. Veterinary sciences, 4(3), . https://doi.org/10.3390/vetsci4030045
Giuliano, Antonio, et al. "Complete Resolution of a Recurrent Canine Anal Sac Squamous Cell Carcinoma with Palliative Radiotherapy and Carboplatin Chemotherapy." Veterinary sciences vol. 4,3 (2017). doi: https://doi.org/10.3390/vetsci4030045
Giuliano A, Dobson J, Mason S. Complete Resolution of a Recurrent Canine Anal Sac Squamous Cell Carcinoma with Palliative Radiotherapy and Carboplatin Chemotherapy. Vet Sci. 2017 Sep 14;4(3). doi: 10.3390/vetsci4030045. PMID: 29056703; PMCID: PMC5644661.
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Vet Sci. 2017 Sep 14;4(3). doi: 10.3390/vetsci4030045.

Complete Resolution of a Recurrent Canine Anal Sac Squamous Cell Carcinoma with Palliative Radiotherapy and Carboplatin Chemotherapy.

Veterinary sciences

Antonio Giuliano, Jane Dobson, Sarah Mason

Affiliations

  1. Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK. [email protected].
  2. Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK. [email protected].
  3. Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK. [email protected].

PMID: 29056703 PMCID: PMC5644661 DOI: 10.3390/vetsci4030045

Abstract

Anal sac squamous cell carcinoma (SCC) is a rare tumor in dogs. Only eight cases have been described in the literature, and previous reports of treatment only describe surgery or palliative treatment with non-steroidal anti-inflammatory drugs. We report a case of a 12-year-old female neutered Labrador with locally advanced anal sac SCC. The dog was treated with four cycles of carboplatin 300 mg/m² and four weekly fractions of 8.5 Gy radiation. The dog achieved a complete response, and one year later the dog is still alive and well with no evidence of tumor recurrence. Radiotherapy in combination with carboplatin chemotherapy was effective in the long-term control of this rare disease.

Keywords: anal sac squamous cell carcinoma; carboplatin; radiotherapy

Conflict of interest statement

The authors declare no conflict of interest.

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