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Eckstrand CD, Hillman C, Murphy BG. Sequence Instability in the Proviral Long Terminal Repeat and gag Regions from Peripheral Blood and Tissue-Derived Leukocytes of FIV-Infected Cats during the Late Asymptomatic Phase. Vet Sci. 2016;3(2)doi: 10.3390/vetsci3020010.
Eckstrand, C. D., Hillman, C., & Murphy, B. G. (2016). Sequence Instability in the Proviral Long Terminal Repeat and gag Regions from Peripheral Blood and Tissue-Derived Leukocytes of FIV-Infected Cats during the Late Asymptomatic Phase. Veterinary sciences, 3(2), . https://doi.org/10.3390/vetsci3020010
Eckstrand, Christina D, et al. "Sequence Instability in the Proviral Long Terminal Repeat and gag Regions from Peripheral Blood and Tissue-Derived Leukocytes of FIV-Infected Cats during the Late Asymptomatic Phase." Veterinary sciences vol. 3,2 (2016). doi: https://doi.org/10.3390/vetsci3020010
Eckstrand CD, Hillman C, Murphy BG. Sequence Instability in the Proviral Long Terminal Repeat and gag Regions from Peripheral Blood and Tissue-Derived Leukocytes of FIV-Infected Cats during the Late Asymptomatic Phase. Vet Sci. 2016 Jun 06;3(2). doi: 10.3390/vetsci3020010. PMID: 29056720; PMCID: PMC5644627.
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Vet Sci. 2016 Jun 06;3(2). doi: 10.3390/vetsci3020010.

Sequence Instability in the Proviral Long Terminal Repeat and gag Regions from Peripheral Blood and Tissue-Derived Leukocytes of FIV-Infected Cats during the Late Asymptomatic Phase.

Veterinary sciences

Christina D Eckstrand, Chadwick Hillman, Brian G Murphy

Affiliations

  1. Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, 4206 Vet Med 3A, University of California, Davis, CA 95616, USA. [email protected].
  2. Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, 4206 Vet Med 3A, University of California, Davis, CA 95616, USA. [email protected].
  3. Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, 4206 Vet Med 3A, University of California, Davis, CA 95616, USA. [email protected].

PMID: 29056720 PMCID: PMC5644627 DOI: 10.3390/vetsci3020010

Abstract

Feline immunodeficiency virus (FIV) infection results in viral persistence, a prolonged asymptomatic phase, and progressive immunopathology. During the asymptomatic phase, a cohort of experimentally FIV-infected cats exhibits features of viral latency in blood suggestive of inactive viral replication. We sought to investigate viral replication activity and genomic stability of the FIV proviral long terminal repeat (LTR) and the 5' aspect of

Keywords: FIV; LTR; asymptomatic; gag; latency; lentivirus; lymph node; promoter

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