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Hong MJ, Na DG, Kim SJ, et al. Role of core needle biopsy as a first-line diagnostic tool for thyroid nodules: a retrospective cohort study. Ultrasonography. 2017;37(3):244-253doi: 10.14366/usg.17041.
Hong, M. J., Na, D. G., Kim, S. J., & Kim, D. S. (2018). Role of core needle biopsy as a first-line diagnostic tool for thyroid nodules: a retrospective cohort study. Ultrasonography (Seoul, Korea), 37(3), 244-253. https://doi.org/10.14366/usg.17041
Hong, Min Ji, et al. "Role of core needle biopsy as a first-line diagnostic tool for thyroid nodules: a retrospective cohort study." Ultrasonography (Seoul, Korea) vol. 37,3 (2018): 244-253. doi: https://doi.org/10.14366/usg.17041
Hong MJ, Na DG, Kim SJ, Kim DS. Role of core needle biopsy as a first-line diagnostic tool for thyroid nodules: a retrospective cohort study. Ultrasonography. 2018 Jul;37(3):244-253. doi: 10.14366/usg.17041. Epub 2017 Sep 15. PMID: 29113031; PMCID: PMC6044216.
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Ultrasonography. 2018 Jul;37(3):244-253. doi: 10.14366/usg.17041. Epub 2017 Sep 15.

Role of core needle biopsy as a first-line diagnostic tool for thyroid nodules: a retrospective cohort study.

Ultrasonography (Seoul, Korea)

Min Ji Hong, Dong Gyu Na, Soo Jin Kim, Dae Sik Kim

Affiliations

  1. Department of Radiology, Gachon University Gil Medical Center, Incheon, Korea.
  2. Department of Radiology, Gangneung Asan Hospital, Gangneung, Korea.
  3. Department of Radiology, Human Medical Imaging and Intervention Center, Seoul, Korea.
  4. Department of Radiology, New Korea Hospital, Gimpo, Korea.
  5. Department of Radiology, Incheon Medical Center, Incheon, Korea.

PMID: 29113031 PMCID: PMC6044216 DOI: 10.14366/usg.17041

Abstract

PURPOSE: The purpose of this study was to evaluate the diagnostic efficacy of fine-needle aspiration (FNA), core needle biopsy (CNB), and combined FNA/CNB for the first-line diagnosis of thyroid nodules.

METHODS: A total of 782 consecutive nodules that underwent simultaneous FNA and CNB were analyzed in this study. We compared the rate of inconclusive results and the diagnostic values for malignancy among FNA, CNB, and combined FNA/CNB.

RESULTS: CNB showed a lower rate (10.2%) of inconclusive results than FNA (23.7%) (P<0.001). Combined FNA/CNB showed a lower rate (6.5%) of inconclusive results than FNA (all nodules, P<0.001; macronodules, P<0.001; and micronodules, P<0.001, respectively) or CNB (all nodules, P<0.001; macronodules, P<0.001; and micronodules, P=0.003, respectively). Combined FNA/ CNB and CNB showed significantly higher sensitivity, accuracy, and diagnostic performance for malignancy as defined by criterion 1 (Bethesda category VI) or criterion 2 (Bethesda categories IV/V/VI) than FNA (P<0.001). However, there was no significant difference in the sensitivity, accuracy, or diagnostic performance between combined FNA/CNB and CNB (with criterion 1, P=0.063, P=0.063, and P=0.412, respectively; with criterion 2, P=0.500, P=0.500, and P=0.348, respectively).

CONCLUSION: CNB was found to be more effective than FNA for the diagnosis of thyroid nodules, and its sensitivity and diagnostic performance for malignancy were similar to those of combined FNA/CNB. CNB has the potential to be an effective alternative first-line diagnostic tool for thyroid nodules when performed by an experienced operator.

Keywords: Biopsy, fine-needle; Biopsy, large-core needle; Thyroid neoplasms; Ultrasonography; Thyroid nodule

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