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Chay KO, Nam Koong KY, Hwang S, et al. NADPH Oxidase Mediates β-Amyloid Peptide-Induced Neuronal Death in Mouse Cortical Cultures. Chonnam Med J. 2017;53(3):196-202doi: 10.4068/cmj.2017.53.3.196.
Chay, K. O., Nam Koong, K. Y., Hwang, S., Kim, J. K., & Bae, C. S. (2017). NADPH Oxidase Mediates β-Amyloid Peptide-Induced Neuronal Death in Mouse Cortical Cultures. Chonnam medical journal, 53(3), 196-202. https://doi.org/10.4068/cmj.2017.53.3.196
Chay, Kee-Oh, et al. "NADPH Oxidase Mediates β-Amyloid Peptide-Induced Neuronal Death in Mouse Cortical Cultures." Chonnam medical journal vol. 53,3 (2017): 196-202. doi: https://doi.org/10.4068/cmj.2017.53.3.196
Chay KO, Nam Koong KY, Hwang S, Kim JK, Bae CS. NADPH Oxidase Mediates β-Amyloid Peptide-Induced Neuronal Death in Mouse Cortical Cultures. Chonnam Med J. 2017 Sep;53(3):196-202. doi: 10.4068/cmj.2017.53.3.196. Epub 2017 Sep 25. PMID: 29026707; PMCID: PMC5636758.
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Chonnam Med J. 2017 Sep;53(3):196-202. doi: 10.4068/cmj.2017.53.3.196. Epub 2017 Sep 25.

NADPH Oxidase Mediates β-Amyloid Peptide-Induced Neuronal Death in Mouse Cortical Cultures.

Chonnam medical journal

Kee-Oh Chay, Kyoung Young Nam Koong, Shinae Hwang, Jong-Keun Kim, Choon Sang Bae

Affiliations

  1. Department of Biochemistry, Chonnam National University Medical School, Gwangju, Korea.
  2. Department of Anatomy, Chonnam National University Medical School, Gwangju, Korea.
  3. Department of Pharmacology, Chonnam National University Medical School, Gwangju, Korea.

PMID: 29026707 PMCID: PMC5636758 DOI: 10.4068/cmj.2017.53.3.196

Abstract

β-Amyloid peptide (Aβ) is the main component of senile plaques in patients with Alzheimer's disease, and is known to be a main pathogenic factor of the disease. Recent evidence indicates that activation of NADPH oxidase (NOX) in microglia or astrocytes may be a source of Aβ-induced reactive oxygen species (ROS). We investigated the role of neuronal NOX in Aβ-induced neuronal death in mouse mixed cortical cultures. Cell death was assessed by measuring lactate dehydrogenase efflux to bathing media 24 or 48 hr after exposure to Aβ

Keywords: Alzheimer Disease; Amyloid beta-Peptides; NADPH Oxidase; Reactive Oxygen Species

Conflict of interest statement

CONFLICT OF INTEREST STATEMENT: None declared.

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