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Sidi S, Bouchier-Hayes L. Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation. Mol Cell Oncol. 2017;4(5):e1348325doi: 10.1080/23723556.2017.1348325.
Sidi, S., & Bouchier-Hayes, L. (2017). Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation. Molecular & cellular oncology, 4(5), e1348325. https://doi.org/10.1080/23723556.2017.1348325
Sidi, Samuel, and Bouchier-Hayes, Lisa. "Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation." Molecular & cellular oncology vol. 4,5 (2017): e1348325. doi: https://doi.org/10.1080/23723556.2017.1348325
Sidi S, Bouchier-Hayes L. Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation. Mol Cell Oncol. 2017 Jul 05;4(5):e1348325. doi: 10.1080/23723556.2017.1348325. eCollection 2017. PMID: 29057309; PMCID: PMC5644479.
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Mol Cell Oncol. 2017 Jul 05;4(5):e1348325. doi: 10.1080/23723556.2017.1348325. eCollection 2017.

Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation.

Molecular & cellular oncology

Samuel Sidi, Lisa Bouchier-Hayes

Affiliations

  1. Department of Medicine, Division of Hematology/Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  2. Department of Developmental and Regenerative Biology Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  3. Department of Pediatrics, Division of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA.
  4. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.

PMID: 29057309 PMCID: PMC5644479 DOI: 10.1080/23723556.2017.1348325

Abstract

Despite being frequently mutated or deregulated in acute myeloid leukemia (AML) and many other cancers, the mechanisms by which nucleophosmin (NPM1) regulates oncogenesis remain elusive. We found that NPM1 plays a direct and conserved role in DNA damage-induced assembly of the PIDDosome complex, the activating platform for caspase-2. This function is carried in the nucleolus and is essential for caspase-2-mediated apoptosis in response to a variety of DNA injuries.

Keywords: Apoptosis; DNA damage; NPM1; PIDD; PIDDosome; RAIDD; caspase-2; nucleolus

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