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Esteban-Martínez L, Sierra-Filardi E, Boya P. Mitophagy, metabolism, and cell fate. Mol Cell Oncol. 2017;4(5):e1353854doi: 10.1080/23723556.2017.1353854.
Esteban-Martínez, L., Sierra-Filardi, E., & Boya, P. (2017). Mitophagy, metabolism, and cell fate. Molecular & cellular oncology, 4(5), e1353854. https://doi.org/10.1080/23723556.2017.1353854
Esteban-Martínez, Lorena, et al. "Mitophagy, metabolism, and cell fate." Molecular & cellular oncology vol. 4,5 (2017): e1353854. doi: https://doi.org/10.1080/23723556.2017.1353854
Esteban-Martínez L, Sierra-Filardi E, Boya P. Mitophagy, metabolism, and cell fate. Mol Cell Oncol. 2017 Jul 17;4(5):e1353854. doi: 10.1080/23723556.2017.1353854. eCollection 2017. PMID: 29057310; PMCID: PMC5644481.
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Mol Cell Oncol. 2017 Jul 17;4(5):e1353854. doi: 10.1080/23723556.2017.1353854. eCollection 2017.

Mitophagy, metabolism, and cell fate.

Molecular & cellular oncology

Lorena Esteban-Martínez, Elena Sierra-Filardi, Patricia Boya

Affiliations

  1. Departament of Cellular and Molecular Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.

PMID: 29057310 PMCID: PMC5644481 DOI: 10.1080/23723556.2017.1353854

Abstract

Mitophagy is the process by which cells eliminate damaged or superfluous mitochondria by degrading them within lysosomes. We show that during development, selective removal of mitochondria by autophagy induces a metabolic shift toward glycolysis that is essential for differentiation of several cell types. These findings suggest potential applications of cell-fate manipulation strategies targeting mitophagy.

Keywords: Autophagy; BNiP3L; hypoxia; metabolic reprogramming

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