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Yang CH, Liu Z, Dong D, et al. Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity. Front Cell Neurosci. 2017;11:315doi: 10.3389/fncel.2017.00315.
Yang, C. H., Liu, Z., Dong, D., Schacht, J., Arya, D., & Sha, S. H. (2017). Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity. Frontiers in cellular neuroscience, 11315. https://doi.org/10.3389/fncel.2017.00315
Yang, Chao-Hui, et al. "Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity." Frontiers in cellular neuroscience vol. 11 (2017): 315. doi: https://doi.org/10.3389/fncel.2017.00315
Yang CH, Liu Z, Dong D, Schacht J, Arya D, Sha SH. Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity. Front Cell Neurosci. 2017 Oct 24;11:315. doi: 10.3389/fncel.2017.00315. eCollection 2017. PMID: 29114207; PMCID: PMC5660723.
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Front Cell Neurosci. 2017 Oct 24;11:315. doi: 10.3389/fncel.2017.00315. eCollection 2017.

Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity.

Frontiers in cellular neuroscience

Chao-Hui Yang, Zhiqi Liu, Deanna Dong, Jochen Schacht, Dev Arya, Su-Hua Sha

Affiliations

  1. Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI, United States.
  2. Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
  3. Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States.
  4. Department of Chemistry, Clemson University, Clemson, SC, United States.

PMID: 29114207 PMCID: PMC5660723 DOI: 10.3389/fncel.2017.00315

Abstract

Previous studies have reported that modification of histones alters aminoglycoside-induced hair cell death and hearing loss. In this study, we investigated three FDA-approved histone deacetylase (HDAC) inhibitors (vorinostat/SAHA, belinostat, and panobinostat) as protectants against aminoglycoside-induced ototoxicity in murine cochlear explants and

Keywords: HDAC inhibitors; acute and chronic animal models; modification of histone acetylation; ototoxicity; prevention of aminoglycoside-induced hearing loss

References

  1. Nat Rev Drug Discov. 2014 Sep;13(9):673-91 - PubMed
  2. Redox Biol. 2015 Aug;5:275-89 - PubMed
  3. Audiol Neurootol. 2001 May-Jun;6(3):117-23 - PubMed
  4. J Neurochem. 2009 Mar;108(5):1226-36 - PubMed
  5. Pharmacol Res. 2010 Jul;62(1):11-7 - PubMed
  6. PLoS One. 2013 Apr 23;8(4):e61999 - PubMed
  7. Brain Res. 2004 Sep 3;1019(1-2):201-9 - PubMed
  8. Am J Otolaryngol. 2015 Mar-Apr;36(2):242-8 - PubMed
  9. Antioxid Redox Signal. 2015 May 20;22(15):1308-24 - PubMed
  10. J Assoc Res Otolaryngol. 2016 Aug;17 (4):289-302 - PubMed
  11. Cell Death Discov. 2015 ;1: - PubMed
  12. Cell Death Differ. 2006 Jan;13(1):20-30 - PubMed
  13. Transl Stroke Res. 2011 Jun 4;2(3):411-23 - PubMed
  14. Lab Invest. 1999 Jul;79(7):807-13 - PubMed
  15. Int J Mol Med. 2015 Aug;36(2):534-40 - PubMed
  16. Nat Rev Cancer. 2001 Dec;1(3):194-202 - PubMed
  17. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2041-6 - PubMed
  18. Free Radic Biol Med. 1999 Feb;26(3-4):341-7 - PubMed
  19. Hear Res. 2001 Aug;158(1-2):165-78 - PubMed
  20. Mol Brain. 2014 May 15;7:37 - PubMed
  21. Hear Res. 2000 Apr;142(1-2):34-40 - PubMed
  22. Audiol Neurootol. 1999 Sep-Oct;4(5):229-36 - PubMed

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