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Kortland LM, Knake S, von Podewils F, et al. Socioeconomic Outcome and Quality of Life in Adults after Status Epilepticus: A Multicenter, Longitudinal, Matched Case-Control Analysis from Germany. Front Neurol. 2017;8:507doi: 10.3389/fneur.2017.00507.
Kortland, L. M., Knake, S., von Podewils, F., Rosenow, F., & Strzelczyk, A. (2017). Socioeconomic Outcome and Quality of Life in Adults after Status Epilepticus: A Multicenter, Longitudinal, Matched Case-Control Analysis from Germany. Frontiers in neurology, 8507. https://doi.org/10.3389/fneur.2017.00507
Kortland, Lena-Marie, et al. "Socioeconomic Outcome and Quality of Life in Adults after Status Epilepticus: A Multicenter, Longitudinal, Matched Case-Control Analysis from Germany." Frontiers in neurology vol. 8 (2017): 507. doi: https://doi.org/10.3389/fneur.2017.00507
Kortland LM, Knake S, von Podewils F, Rosenow F, Strzelczyk A. Socioeconomic Outcome and Quality of Life in Adults after Status Epilepticus: A Multicenter, Longitudinal, Matched Case-Control Analysis from Germany. Front Neurol. 2017 Sep 26;8:507. doi: 10.3389/fneur.2017.00507. eCollection 2017. PMID: 29018404; PMCID: PMC5622933.
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Front Neurol. 2017 Sep 26;8:507. doi: 10.3389/fneur.2017.00507. eCollection 2017.

Socioeconomic Outcome and Quality of Life in Adults after Status Epilepticus: A Multicenter, Longitudinal, Matched Case-Control Analysis from Germany.

Frontiers in neurology

Lena-Marie Kortland, Susanne Knake, Felix von Podewils, Felix Rosenow, Adam Strzelczyk

Affiliations

  1. Epilepsy Center Hessen, Philipps-University, Marburg, Germany.
  2. Epilepsy Center Greifswald, Ernst-Moritz-Arndt-University, Greifswald, Germany.
  3. Epilepsy Center Frankfurt Rhine-Main, Goethe-University, Frankfurt am Main, Germany.

PMID: 29018404 PMCID: PMC5622933 DOI: 10.3389/fneur.2017.00507

Abstract

BACKGROUND: There is a lack of data concerning socioeconomic outcome and quality of life (QoL) in patients after status epilepticus (SE) in Germany.

PATIENTS AND METHODS: Adult patients treated between 2011 and 2015 due to SE at the university hospitals in Frankfurt, Greifswald, and Marburg were asked to fill out a questionnaire regarding long-term outcome of at least 3 months after discharge. The SE cohort consisted of 25.9% patients with an acute symptomatic, 42% with a remote symptomatic and previous epilepsy, 22.2% with a new-onset remote symptomatic, and 9.9% with other or unknown etiology. A matched case-control analysis was applied for comparison with patients with drug refractory epilepsy and seizure remission, both not previously affected by SE.

RESULTS: A total of 81 patients (mean age: 58.7 ± 18.0 years; 58% female) participated. A non-refractory course was present in 59.3%, while 27.2% had a refractory SE (RSE) and 13.6% had a superrefractory SE (SRSE). Before admission, a favorable modified Rankin Scale (mRS) of 0-3 was found in 82.7% (67/81), deteriorating to 38.3% (31/81) (

DISCUSSION: Patients after SE show substantial impairments in their QoL and daily life activities. However, in the long term, patients with RSE and SRSE had a relatively favorable outcome comparable to that of patients with a non-refractory SE course. This underlines the need for efficient therapeutic options in SE.

Keywords: anticonvulsants; epilepsy; morbidity; mortality; seizure

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