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Org Biomol Chem. 2017 Nov 22;15(45):9575-9578. doi: 10.1039/c7ob02091k.

A general method of Suzuki-Miyaura cross-coupling of 4- and 5-halo-1,2,3-triazoles in water.

Organic & biomolecular chemistry

Pavel S Gribanov, Gleb A Chesnokov, Maxim A Topchiy, Andrey F Asachenko, Mikhail S Nechaev

Affiliations

  1. A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 119991 Moscow, Leninskiy prospect 29, Russian Federation. [email protected].

PMID: 29114680 DOI: 10.1039/c7ob02091k

Abstract

A general method of the synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by Suzuki-Miyaura cross-coupling from 4- and 5-halo-1,2,3-triazoles is reported. The reaction is mediated by an expanded-ring N-heterocyclic carbene palladium complex in water. The developed reaction protocol meets the requirements of "green chemistry". Cross-coupling of 4- and 5-chlorotriazoles is reported for the first time.

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