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Huang F, Zhao JL, Wang L, et al. miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages. Front Immunol. 2017;8:1327doi: 10.3389/fimmu.2017.01327.
Huang, F., Zhao, J. L., Wang, L., Gao, C. C., Liang, S. Q., An, D. J., Bai, J., Chen, Y., Han, H., & Qin, H. Y. (2017). miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages. Frontiers in immunology, 81327. https://doi.org/10.3389/fimmu.2017.01327
Huang, Fei, et al. "miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages." Frontiers in immunology vol. 8 (2017): 1327. doi: https://doi.org/10.3389/fimmu.2017.01327
Huang F, Zhao JL, Wang L, Gao CC, Liang SQ, An DJ, Bai J, Chen Y, Han H, Qin HY. miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages. Front Immunol. 2017 Oct 16;8:1327. doi: 10.3389/fimmu.2017.01327. eCollection 2017. PMID: 29085372; PMCID: PMC5650608.
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Front Immunol. 2017 Oct 16;8:1327. doi: 10.3389/fimmu.2017.01327. eCollection 2017.

miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages.

Frontiers in immunology

Fei Huang, Jun-Long Zhao, Liang Wang, Chun-Chen Gao, Shi-Qian Liang, Dong-Jie An, Jian Bai, Yan Chen, Hua Han, Hong-Yan Qin

Affiliations

  1. State Key Laboratory of Cancer Biology, Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi'an, China.
  2. Department of Stomatology, PLA Navy General Hospital, Beijing, China.
  3. Department of Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

PMID: 29085372 PMCID: PMC5650608 DOI: 10.3389/fimmu.2017.01327

Abstract

The Notch pathway plays critical roles in the differentiation and polarized activation of macrophages; however, the downstream molecular mechanisms underlying Notch activity in macrophages remain elusive. Our previous study has identified a group of microRNAs that mediate Notch signaling to regulate macrophage activation and tumor-associated macrophages (TAMs). In this study, we demonstrated that miR-148a-3p functions as a novel downstream molecule of Notch signaling to promote the differentiation of monocytes into macrophages in the presence of granulocyte macrophage colony-stimulating factor (GM-CSF). Meanwhile, miR-148a-3p promoted M1 and inhibited M2 polarization of macrophages upon Notch activation. Macrophages overexpressing miR-148a-3p exhibited enhanced ability to engulf and kill bacteria, which was mediated by excessive production of reactive oxygen species (ROS). Further studies using reporter assay and Western blotting identified

Keywords: NF-κB; Notch signaling; PTEN; macrophages; miR-148a-3p

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