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Chung JY, Kim YS, Kim Y, et al. Regulation of Inflammation by Sucrose Isomer, Turanose, in Raw 264.7 Cells. J Cancer Prev. 2017;22(3):195-201doi: 10.15430/JCP.2017.22.3.195.
Chung, J. Y., Kim, Y. S., Kim, Y., & Yoo, S. H. (2017). Regulation of Inflammation by Sucrose Isomer, Turanose, in Raw 264.7 Cells. Journal of cancer prevention, 22(3), 195-201. https://doi.org/10.15430/JCP.2017.22.3.195
Chung, Joo-Yeon, et al. "Regulation of Inflammation by Sucrose Isomer, Turanose, in Raw 264.7 Cells." Journal of cancer prevention vol. 22,3 (2017): 195-201. doi: https://doi.org/10.15430/JCP.2017.22.3.195
Chung JY, Kim YS, Kim Y, Yoo SH. Regulation of Inflammation by Sucrose Isomer, Turanose, in Raw 264.7 Cells. J Cancer Prev. 2017 Sep;22(3):195-201. doi: 10.15430/JCP.2017.22.3.195. Epub 2017 Sep 30. PMID: 29018785; PMCID: PMC5624461.
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J Cancer Prev. 2017 Sep;22(3):195-201. doi: 10.15430/JCP.2017.22.3.195. Epub 2017 Sep 30.

Regulation of Inflammation by Sucrose Isomer, Turanose, in Raw 264.7 Cells.

Journal of cancer prevention

Joo-Yeon Chung, Yoo-Sun Kim, Yuri Kim, Sang-Ho Yoo

Affiliations

  1. Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Korea.
  2. Department of Food Science and Biotechnology, and Carbohydrate Bioproduct Research Center, Sejong University, Seoul, Korea.

PMID: 29018785 PMCID: PMC5624461 DOI: 10.15430/JCP.2017.22.3.195

Abstract

Increased sugar consumption has been proposed to be a risk factor for obesity-related metabolic disorders. The objective of this study was to investigate the anti-inflammatory effect of turanose in Raw 264.7 macrophages. Turanose (3-O-α-D-glucosyl-D-fructose), an isomer of sucrose, naturally exists in honey. For these studies, macrophages were treated with total glucose (Glu), 50% Glu/50% turanose (T50), 25% Glu/75% turanose (T75), and 100% turanose (T100), each with a total concentration of 25 mM in cell media. Expressions of inflammatory enzymes and cytokines were analyzed. Cell viability was not affected in the turanose treated groups compared to the Glu group. Lipopolysaccharide and glucose-induced nitric oxide production, protein expression of inducible nitric oxide synthase, COX-2, and superoxide dismutase 2, and mRNA expression levels of interleukin (IL)-1β and IL-18 were significantly suppressed by turanose treatment. These results demonstrate that turanose exerts anti-inflammatory effects in vitro, and possesses potential to serve therapeutic functional sweetener for testing in vivo and in clinical trials.

Keywords: Inflammation; Macrophages; Sweetening agents; Turanose

Conflict of interest statement

CONFLICTS OF INTEREST No potential conflicts of interest were disclosed.

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