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Xin B, Cui Y, Wang Y, et al. Combined use of alcohol in conventional chemical-induced mouse liver cancer model improves the simulation of clinical characteristics of human hepatocellular carcinoma. Oncol Lett. 2017;14(4):4722-4728doi: 10.3892/ol.2017.6800.
Xin, B., Cui, Y., Wang, Y., Wang, L., Yin, J., Zhang, L., Pang, H., Zhang, H., & Wang, R. A. (2017). Combined use of alcohol in conventional chemical-induced mouse liver cancer model improves the simulation of clinical characteristics of human hepatocellular carcinoma. Oncology letters, 14(4), 4722-4728. https://doi.org/10.3892/ol.2017.6800
Xin, Bo, et al. "Combined use of alcohol in conventional chemical-induced mouse liver cancer model improves the simulation of clinical characteristics of human hepatocellular carcinoma." Oncology letters vol. 14,4 (2017): 4722-4728. doi: https://doi.org/10.3892/ol.2017.6800
Xin B, Cui Y, Wang Y, Wang L, Yin J, Zhang L, Pang H, Zhang H, Wang RA. Combined use of alcohol in conventional chemical-induced mouse liver cancer model improves the simulation of clinical characteristics of human hepatocellular carcinoma. Oncol Lett. 2017 Oct;14(4):4722-4728. doi: 10.3892/ol.2017.6800. Epub 2017 Aug 23. PMID: 29085472; PMCID: PMC5649534.
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Oncol Lett. 2017 Oct;14(4):4722-4728. doi: 10.3892/ol.2017.6800. Epub 2017 Aug 23.

Combined use of alcohol in conventional chemical-induced mouse liver cancer model improves the simulation of clinical characteristics of human hepatocellular carcinoma.

Oncology letters

Bo Xin, Ying Cui, Yanxia Wang, Lei Wang, Jipeng Yin, Licheng Zhang, Hailin Pang, Helong Zhang, Rui-An Wang

Affiliations

  1. Department of Oncology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China.
  2. Department of Oncology, No. 88 Hospital of People's Liberation Army, Tai'an, Shandong 271000, P.R. China.
  3. Department of Transfusion, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China.
  4. Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.
  5. State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.
  6. State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.

PMID: 29085472 PMCID: PMC5649534 DOI: 10.3892/ol.2017.6800

Abstract

Liver cancer is the one of most common types of cancer and the 2nd cause of cancer-associated mortalities worldwide. Establishing appropriate animal models of liver cancer is essential for basic and translational studies. The present study evaluated the effects of the combined use of alcohol with a conventional chemical-induced mouse liver cancer model. The treatment of alcohol/diethylnitrosamine (DEN)/carbon tetrachloride (CCl

Keywords: alcohol; carcinogenesis; hepatic lesions; histology; murine

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