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Inaguma S, Lasota J, Felisiak-Golabek A, et al. Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD-L1 (CD274)-expression: Possible roles of tumour micro environmental factors for CD274 expression. J Pathol Clin Res. 2017;3(4):268-278doi: 10.1002/cjp2.81.
Inaguma, S., Lasota, J., Felisiak-Golabek, A., Kowalik, A., Wang, Z., Zieba, S., Kalisz, J., Ikeda, H., & Miettinen, M. (2017). Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD-L1 (CD274)-expression: Possible roles of tumour micro environmental factors for CD274 expression. The journal of pathology. Clinical research, 3(4), 268-278. https://doi.org/10.1002/cjp2.81
Inaguma, Shingo, et al. "Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD-L1 (CD274)-expression: Possible roles of tumour micro environmental factors for CD274 expression." The journal of pathology. Clinical research vol. 3,4 (2017): 268-278. doi: https://doi.org/10.1002/cjp2.81
Inaguma S, Lasota J, Felisiak-Golabek A, Kowalik A, Wang Z, Zieba S, Kalisz J, Ikeda H, Miettinen M. Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD-L1 (CD274)-expression: Possible roles of tumour micro environmental factors for CD274 expression. J Pathol Clin Res. 2017 Oct 07;3(4):268-278. doi: 10.1002/cjp2.81. eCollection 2017 Oct. PMID: 29085667; PMCID: PMC5653930.
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J Pathol Clin Res. 2017 Oct 07;3(4):268-278. doi: 10.1002/cjp2.81. eCollection 2017 Oct.

Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD-L1 (CD274)-expression: Possible roles of tumour micro environmental factors for CD274 expression.

The journal of pathology. Clinical research

Shingo Inaguma, Jerzy Lasota, Anna Felisiak-Golabek, Artur Kowalik, Zengfeng Wang, Sebastian Zieba, Joanna Kalisz, Hiroshi Ikeda, Markku Miettinen

Affiliations

  1. Laboratory of PathologyNational Cancer InstituteBethesdaMDUSA.
  2. Department of PathologyAichi Medical University School of MedicineNagakuteAichiJapan.
  3. Department of Molecular DiagnosticsHolycross Cancer CenterKielcePoland.

PMID: 29085667 PMCID: PMC5653930 DOI: 10.1002/cjp2.81

Abstract

Aberrant PD-L1 (CD274) expression has been described in different types of tumour and linked to tumour aggressiveness and a poor prognosis. In primary colorectal carcinomas (CRCs), CD274 expression was reported to be associated with mismatch repair (MMR)-deficiency,

Keywords: ALCAM (CD166); BRAF; CD274 (PD‐L1); CDX2; IFNγ; KRAS; TGF‐β1; immunohistochemistry; metastatic colorectal carcinoma

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