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J Pathol Clin Res. 2017 Oct 14;3(4):279-293. doi: 10.1002/cjp2.82. eCollection 2017 Oct.

Evaluation of endometrial carcinoma prognostic immunohistochemistry markers in the context of molecular classification.

The journal of pathology. Clinical research

Anthony N Karnezis, Samuel Leung, Jamie Magrill, Melissa K McConechy, Winnie Yang, Christine Chow, Martin Kobel, Cheng-Han Lee, David G Huntsman, Aline Talhouk, Friederich Kommoss, C Blake Gilks, Jessica N McAlpine

Affiliations

  1. Department of Pathology and Laboratory MedicineUniversity of British ColumbiaVancouverBCCanada.
  2. BC Cancer AgencyVancouverBCCanada.
  3. Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation CentreUniversity of British ColumbiaVancouverBCCanada.
  4. Department of Human GeneticsMcGill University, Research Institute of the McGill University Health NetworkMontrealQCCanada.
  5. Department of PathologyTom Baker Cancer CenterCalgaryABCanada.
  6. Department of Gynecology and Obstetrics, Division of Gynecologic OncologyUniversity of British ColumbiaVancouverBCCanada.

PMID: 29085668 PMCID: PMC5653931 DOI: 10.1002/cjp2.82

Abstract

Molecular subclassification of endometrial carcinoma (EC) with Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) identifies four subtypes [DNA polymerase epsilon (

Keywords: L1CAM; ProMisE; TCGA; biomarker; endometrial cancer; estrogen receptor; progesterone receptor; prognosis

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