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Kennedy I, Francis H, Meng F, et al. Diagnostic and therapeutic potentials of microRNAs in cholangiopathies. Liver Res. 2017;1(1):34-41doi: 10.1016/j.livres.2017.03.003.
Kennedy, I., Francis, H., Meng, F., Glaser, S., & Alpini, G. (2017). Diagnostic and therapeutic potentials of microRNAs in cholangiopathies. Liver research, 1(1), 34-41. https://doi.org/10.1016/j.livres.2017.03.003
Kennedy, Indsey, et al. "Diagnostic and therapeutic potentials of microRNAs in cholangiopathies." Liver research vol. 1,1 (2017): 34-41. doi: https://doi.org/10.1016/j.livres.2017.03.003
Kennedy I, Francis H, Meng F, Glaser S, Alpini G. Diagnostic and therapeutic potentials of microRNAs in cholangiopathies. Liver Res. 2017 Jun;1(1):34-41. doi: 10.1016/j.livres.2017.03.003. Epub 2017 Apr 26. PMID: 29085701; PMCID: PMC5659325.
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Liver Res. 2017 Jun;1(1):34-41. doi: 10.1016/j.livres.2017.03.003. Epub 2017 Apr 26.

Diagnostic and therapeutic potentials of microRNAs in cholangiopathies.

Liver research

Indsey Kennedy, Heather Francis, Fanyin Meng, Shannon Glaser, Gianfranco Alpini

Affiliations

  1. Research, Central Texas Veterans Health Care System.
  2. Department of Medicine, Texas A&M Health Science Center, College of Medicine.
  3. Baylor Scott & White Digestive Disease Research Center, Baylor Scott & White Health, Temple, Texas, USA.

PMID: 29085701 PMCID: PMC5659325 DOI: 10.1016/j.livres.2017.03.003

Abstract

Cholangiopathies are a group of rare, devastating diseases that arise from damaged cholangiocytes, the cells that line the intra- and extra-hepatic bile ducts of the biliary epithelium. Cholangiopathies result in significant morbidity and mortality and are a major cause of liver transplantation. A better understanding of the underlying pathogenesis that influences cholangiocyte dysregulation and cholangiopathy progression is necessary, considering the dismal prognosis associated with these diseases. MicroRNAs are a class of small, non-coding RNAs that regulate post-transcriptional mRNA expression of specific genes. The role of microRNAs has expanded to include the initiation and development of many diseases, including cholangiopathies. Understanding microRNA regulation of cholangiopathies may provide diagnostic and therapeutic benefit for these diseases. In this review, the authors primarily focus on studies published within the last five years that help determine the diagnostic and therapeutic potential of microRNAs in cholangiopathies.

Keywords: Cholangiopathies; Diagnosis; Therapy; microRNAs

Conflict of interest statement

The authors have no conflicts of interest to disclose.

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