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Santos F, Nadol JB. Temporal bone histopathology of furosemide ototoxicity. Laryngoscope Investig Otolaryngol. 2017;2(5):204-207doi: 10.1002/lio2.108.
Santos, F., & Nadol, J. B. (2017). Temporal bone histopathology of furosemide ototoxicity. Laryngoscope investigative otolaryngology, 2(5), 204-207. https://doi.org/10.1002/lio2.108
Santos, Felipe, and Nadol, Joseph B. "Temporal bone histopathology of furosemide ototoxicity." Laryngoscope investigative otolaryngology vol. 2,5 (2017): 204-207. doi: https://doi.org/10.1002/lio2.108
Santos F, Nadol JB. Temporal bone histopathology of furosemide ototoxicity. Laryngoscope Investig Otolaryngol. 2017 Sep 25;2(5):204-207. doi: 10.1002/lio2.108. eCollection 2017 Oct. PMID: 29085910; PMCID: PMC5655552.
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Laryngoscope Investig Otolaryngol. 2017 Sep 25;2(5):204-207. doi: 10.1002/lio2.108. eCollection 2017 Oct.

Temporal bone histopathology of furosemide ototoxicity.

Laryngoscope investigative otolaryngology

Felipe Santos, Joseph B Nadol

Affiliations

  1. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary Boston Massachusetts U.S.A.
  2. Department of Otolaryngology Harvard Medical School Boston Massachusetts U.S.A.

PMID: 29085910 PMCID: PMC5655552 DOI: 10.1002/lio2.108

Abstract

OBJECTIVES: To describe the human temporal bone pathology in two patients who incurred furosemide induced ototoxicity.

PATIENTS: 1) A 46-year-old woman in acute liver and renal failure treated with high doses of furosemide for anasarca who developed a rapidly progressive severe-to-profound asymmetric sensorineural hearing loss. 2) A 65-year-old woman with undifferentiated small cell carcinoma of the lung who received intravenous furosemide 1 day prior to death for pulmonary edema.

INTERVENTIONS: Removal of temporal bones, histologic processing, and light microscopy of temporal bones.

MAIN OUTCOME MEASURES: Temporal bone histopathology and correlation with clinical and audiometric data.

RESULTS: All three temporal bones demonstrated edema and cystic changes in the stria vascularis. In the first case the furosemide exposure was associated with hearing loss and the pathological changes were more extensive including cystic changes in the Hensen's cells, collapse of Reissner's membrane and the tectorial membrane and diffuse loss of inner and outer hair cells with only modest reduction in the spiral ganglion cell population. In the second case, without attributable hearing loss, there was only modest reduction in hair cell and spiral ganglion cell counts. Pathological changes were not observed in the ampullae of the semicircular canals or epithelium of the saccular or utricular maculae in either case.

CONCLUSIONS: The temporal bone pathologic correlate for furosemide-induced ototoxicity is edema and cystic degeneration of the stria vascularis. The degree of degenerative change appears dose-dependent. We infer that pathological changes may occur in the absence of a measurable immediate clinical effect.

LEVEL OF EVIDENCE: NA.

Keywords: Ototoxicity; furosemide; sensorineural hearing loss; stria vascularis

References

  1. J Clin Pharmacol. 1981 Nov-Dec;21(11-12 Pt 2):620-7 - PubMed
  2. Acta Otolaryngol. 1989 Jul-Aug;108(1-2):55-61 - PubMed
  3. Otolaryngol Clin North Am. 1993 Oct;26(5):829-44 - PubMed
  4. J Assoc Res Otolaryngol. 2014 Aug;15(4):555-70 - PubMed
  5. Br J Audiol. 1982 May;16(2):109-16 - PubMed
  6. Arch Otolaryngol. 1969 Aug;90(2):152-5 - PubMed
  7. Hear Res. 1993 Dec;71(1-2):202-7 - PubMed
  8. Laryngoscope. 2006 Aug;116(8):1310-20 - PubMed
  9. Laryngoscope. 1976 Aug;86(8):1065-86 - PubMed
  10. Anat Embryol (Berl). 1995 Feb;191(2):101-18 - PubMed
  11. Otol Neurotol. 2014 Sep;35(8):1446-50 - PubMed
  12. Arch Otolaryngol Head Neck Surg. 1993 Jul;119(7):758-61 - PubMed
  13. Toxicol Appl Pharmacol. 1973 Jun;25(2):259-66 - PubMed
  14. Acta Otolaryngol. 1981 May-Jun;91(5-6):399-414 - PubMed

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