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Pfeiffer SA, Rudisch BM, Glaeser P, et al. Continuous purification of reaction products by micro free-flow electrophoresis enabled by large area deep-UV fluorescence imaging. Anal Bioanal Chem. 2017;410(3):853-862doi: 10.1007/s00216-017-0697-8.
Pfeiffer, S. A., Rudisch, B. M., Glaeser, P., Spanka, M., Nitschke, F., Robitzki, A. A., Schneider, C., Nagl, S., & Belder, D. (2018). Continuous purification of reaction products by micro free-flow electrophoresis enabled by large area deep-UV fluorescence imaging. Analytical and bioanalytical chemistry, 410(3), 853-862. https://doi.org/10.1007/s00216-017-0697-8
Pfeiffer, Simon A, et al. "Continuous purification of reaction products by micro free-flow electrophoresis enabled by large area deep-UV fluorescence imaging." Analytical and bioanalytical chemistry vol. 410,3 (2018): 853-862. doi: https://doi.org/10.1007/s00216-017-0697-8
Pfeiffer SA, Rudisch BM, Glaeser P, Spanka M, Nitschke F, Robitzki AA, Schneider C, Nagl S, Belder D. Continuous purification of reaction products by micro free-flow electrophoresis enabled by large area deep-UV fluorescence imaging. Anal Bioanal Chem. 2018 Jan;410(3):853-862. doi: 10.1007/s00216-017-0697-8. Epub 2017 Oct 30. PMID: 29085988.
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Anal Bioanal Chem. 2018 Jan;410(3):853-862. doi: 10.1007/s00216-017-0697-8. Epub 2017 Oct 30.

Continuous purification of reaction products by micro free-flow electrophoresis enabled by large area deep-UV fluorescence imaging.

Analytical and bioanalytical chemistry

Simon A Pfeiffer, Benjamin M Rudisch, Petra Glaeser, Matthias Spanka, Felix Nitschke, Andrea A Robitzki, Christoph Schneider, Stefan Nagl, Detlev Belder

Affiliations

  1. Institut für Analytische Chemie, Universität Leipzig, Johannisallee 29, 04103, Leipzig, Germany.
  2. Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103, Leipzig, Germany.
  3. Center for Biotechnology and Biomedicine, Universität Leipzig, Deutscher Platz 5, 04103, Leipzig, Germany.
  4. Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.
  5. Institut für Analytische Chemie, Universität Leipzig, Johannisallee 29, 04103, Leipzig, Germany. [email protected].

PMID: 29085988 DOI: 10.1007/s00216-017-0697-8

Abstract

Microreactors have gained increasing attention in their application toward continuous micro flow synthesis. An unsolved problem of continuous flow synthesis is the lack of techniques for continuous product purification. Herein, we present a micro free-flow electrophoresis device and accompanying setup that enables the continuous separation and purification of unlabeled organic synthesis products. The system is applied to the separation and purification of triarylmethanes. For imaging of the unlabeled analytes on-chip a novel setup for large area (3.6 cm

Keywords: Continuous flow; Flow microreactor synthesis; Free-flow separation; Ultraviolet fluorescence

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