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Oncotarget. 2017 Jul 18;8(39):64809-64826. doi: 10.18632/oncotarget.19363. eCollection 2017 Sep 12.

Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.

Oncotarget

Diana Gabriel, Dinah Dorith Shafry, Leslie B Gordon, Karima Djabali

Affiliations

  1. Department of Dermatology, Epigenetics of Aging, TUM School of Medicine, Technische Universität München, Garching-Munich, Germany.
  2. Department of Pediatrics, Alpert Medical School of Brown University and Hasbro Children's Hospital, Providence, RI, USA.
  3. Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

PMID: 29029393 PMCID: PMC5630293 DOI: 10.18632/oncotarget.19363

Abstract

Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic condition associated with mutations in the

Keywords: Gerotarget; Ionafarnib; autophagy; lamin; progerin; sulforaphane

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflict of interest.

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