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Pan Z, He H, Tang L, et al. Loss of heterozygosity on chromosome 16q increases relapse risk in Wilms' tumor: a meta-analysis. Oncotarget. 2017;8(39):66467-66475doi: 10.18632/oncotarget.20191.
Pan, Z., He, H., Tang, L., Bu, Q., Cheng, H., Wang, A., Lyu, J., & You, H. (2017). Loss of heterozygosity on chromosome 16q increases relapse risk in Wilms' tumor: a meta-analysis. Oncotarget, 8(39), 66467-66475. https://doi.org/10.18632/oncotarget.20191
Pan, Zhenyu, et al. "Loss of heterozygosity on chromosome 16q increases relapse risk in Wilms' tumor: a meta-analysis." Oncotarget vol. 8,39 (2017): 66467-66475. doi: https://doi.org/10.18632/oncotarget.20191
Pan Z, He H, Tang L, Bu Q, Cheng H, Wang A, Lyu J, You H. Loss of heterozygosity on chromosome 16q increases relapse risk in Wilms' tumor: a meta-analysis. Oncotarget. 2017 Aug 11;8(39):66467-66475. doi: 10.18632/oncotarget.20191. eCollection 2017 Sep 12. PMID: 29029528; PMCID: PMC5630428.
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Oncotarget. 2017 Aug 11;8(39):66467-66475. doi: 10.18632/oncotarget.20191. eCollection 2017 Sep 12.

Loss of heterozygosity on chromosome 16q increases relapse risk in Wilms' tumor: a meta-analysis.

Oncotarget

Zhenyu Pan, Hairong He, Lina Tang, Qingting Bu, Hua Cheng, Anmin Wang, Jun Lyu, Haisheng You

Affiliations

  1. Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
  2. Department of Pharmacy, Xi'an Jiaotong University Affiliated Children's Hospital, Xi'an, Shaanxi, 710003, China.
  3. Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
  4. Department of Genetics, Northwest Women's and Children's Hospital, Xi'an, Shaanxi, 710061, China.

PMID: 29029528 PMCID: PMC5630428 DOI: 10.18632/oncotarget.20191

Abstract

Wilms' tumor (WT) is the most frequent malignant renal tumor in children. The survival rate is lower in patients with recurrence, and the factors that influence relapse in WT are not fully understood. Loss of heterozygosity on chromosome 16q (LOH 16q) has been reported to be associated with the relapse in WT, but this remains controversial. We performed a meta-analysis to clarify this. PUBMED, EMBASE, and the Cochrane Library were searched up to March 17, 2017. Ten studies involving 3385 patients were ultimately included in the meta-analysis. The meta-analysis showed that LOH 16q was significantly associated with the relapse in WT (relative risk [RR] = 1.74, 95% confidence interval [CI] = 1.43-2.13,

Keywords: LOH 16q; Wilms’ tumor; meta-analysis; relapse

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that there is no conflicts of interests regarding the publication of this paper.

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