Display options
Share it on

Oncotarget. 2017 Mar 15;8(39):66540-66549. doi: 10.18632/oncotarget.16239. eCollection 2017 Sep 12.

Is preoperative chronic kidney disease status associated with oncologic outcomes in upper urinary tract urothelial carcinoma? A multicenter propensity score-matched analysis.

Oncotarget

Ho Song Yu, Jun Eul Hwang, Ho Seok Chung, Yang Hyun Cho, Myung Soo Kim, Eu Chang Hwang, Kyung Jin Oh, Sun-Ouck Kim, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Kwangsung Park, Soo Bang Ryu, Sung-Hoon Jung, Young Hoe Hur, Joon Hwa Noh, Myung Ki Kim, Ill Young Seo, Chul-Sung Kim, Sung Gu Kang, Seok Ho Kang, Jun Cheon

Affiliations

  1. Department of Urology, Chonnam National University Medical School, Gwangju, Korea.
  2. Department of Hemato-Oncology, Chonnam National University Medical School, Gwangju, Korea.
  3. Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea.
  4. Department of General Surgery, Chonnam National University Medical School, Gwangju, Korea.
  5. Department of Urology, Kwangju Christian Hospital, Gwangju, Korea.
  6. Department of Urology, Chonbuk National University Medical School, Jeonju, Korea.
  7. Department of Urology, Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
  8. Department of Urology, Chosun University School of Medicine, Gwangju, Korea.
  9. Department of Urology, Korea University College of Medicine, Seoul, Korea.

PMID: 29029534 PMCID: PMC5630434 DOI: 10.18632/oncotarget.16239

Abstract

PURPOSE: The aim of this study was to determine the effect of preoperative chronic kidney disease (CKD) on the prognosis of patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU).

RESULTS: The median follow-up period was 31.1 months (interquartile range: 16.2-55.7 months). Among the study patients, 224 patients in the non-CKD group were selected

METHODS: A total of 566 patients who underwent RNU at 6 institutions from 2004 to 2014 were retrospectively reviewed. Of these patients, 342 had an estimated glomerular filtration rate (eGFR) ≥ 60 ml/min/1.73 m

CONCLUSIONS: Preoperative CKD appears to be an important independent prognostic factor for oncologic outcomes in patients with UTUC.

Keywords: carcinoma; chronic; prognosis; renal insufficiency; transitional cell

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that they have no conflict of interest

References

  1. Stat Med. 1998 Oct 15;17(19):2265-81 - PubMed
  2. Int Urol Nephrol. 2016 Jun;48(6):993-9 - PubMed
  3. J Am Soc Nephrol. 2008 Dec;19(12):2414-9 - PubMed
  4. Cancer. 2010 Jun 15;116(12):2967-73 - PubMed
  5. J Am Soc Nephrol. 2005 Dec;16(12):3728-35 - PubMed
  6. J Urol. 2009 Aug;182(2):451-8; discussion 458 - PubMed
  7. J Am Soc Nephrol. 2003 Jan;14(1):197-207 - PubMed
  8. Ann Intern Med. 1999 Mar 16;130(6):461-70 - PubMed
  9. J Am Soc Nephrol. 2009 Jun;20(6):1341-50 - PubMed
  10. Eur Urol. 2013 Oct;64(4):639-53 - PubMed
  11. World J Urol. 2017 Mar;35(3):337-353 - PubMed
  12. Am J Kidney Dis. 2007 Nov;50(5):743-53 - PubMed
  13. Am J Kidney Dis. 2014 May;63(5):713-35 - PubMed
  14. Medicine (Baltimore). 2016 Apr;95(14):e3255 - PubMed
  15. Clin Chem. 2006 Dec;52(12):2188-93 - PubMed
  16. Kidney Int. 2007 Feb;71(3):239-44 - PubMed
  17. Cancer. 2007 Apr 15;109(8):1487-92 - PubMed
  18. BJU Int. 2009 Nov;104(10):1471-4 - PubMed
  19. N Engl J Med. 2004 Sep 23;351(13):1296-305 - PubMed
  20. Kidney Int. 2005 Jun;67(6):2089-100 - PubMed
  21. Ren Fail. 2016;38(1):77-83 - PubMed
  22. CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29 - PubMed
  23. J Urol. 2000 Nov;164(5):1523-5 - PubMed
  24. Cancer. 2009 Mar 15;115(6):1224-33 - PubMed
  25. Int Urol Nephrol. 2015 Aug;47(8):1335-41 - PubMed
  26. Ann Surg Oncol. 2015 Nov;22(12):4098-103 - PubMed
  27. Urol Oncol. 2013 Nov;31(8):1483-8 - PubMed

Publication Types