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Ñamendys-Silva SA, Ruiz-Beltran AM, Barragán-Dessavre M, et al. Clinical characteristics of critically ill cancer patients who are undergoing isolated limb perfusion. Mol Clin Oncol. 2017;7(5):747-750doi: 10.3892/mco.2017.1401.
Ñamendys-Silva, S. A., Ruiz-Beltran, A. M., Barragán-Dessavre, M., Bautista-Ocampo, A. R., Meneses-García, A., González-Chon, O., & Herrera-Gómez, A. (2017). Clinical characteristics of critically ill cancer patients who are undergoing isolated limb perfusion. Molecular and clinical oncology, 7(5), 747-750. https://doi.org/10.3892/mco.2017.1401
Ñamendys-Silva, Silvio A, et al. "Clinical characteristics of critically ill cancer patients who are undergoing isolated limb perfusion." Molecular and clinical oncology vol. 7,5 (2017): 747-750. doi: https://doi.org/10.3892/mco.2017.1401
Ñamendys-Silva SA, Ruiz-Beltran AM, Barragán-Dessavre M, Bautista-Ocampo AR, Meneses-García A, González-Chon O, Herrera-Gómez A. Clinical characteristics of critically ill cancer patients who are undergoing isolated limb perfusion. Mol Clin Oncol. 2017 Nov;7(5):747-750. doi: 10.3892/mco.2017.1401. Epub 2017 Aug 31. PMID: 29142747; PMCID: PMC5666660.
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Mol Clin Oncol. 2017 Nov;7(5):747-750. doi: 10.3892/mco.2017.1401. Epub 2017 Aug 31.

Clinical characteristics of critically ill cancer patients who are undergoing isolated limb perfusion.

Molecular and clinical oncology

Silvio A Ñamendys-Silva, Arturo M Ruiz-Beltran, Mireya Barragán-Dessavre, Andoreni R Bautista-Ocampo, Abelardo Meneses-García, Octavio González-Chon, Angel Herrera-Gómez

Affiliations

  1. Department of Critical Care Medicine, Instituto Nacional de Cancerología, Mexico City 14080, Mexico.
  2. Department of Critical Care Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
  3. Department of Critical Care Medicine, Fundación Clínica Médica Sur, Mexico City 14050, Mexico.

PMID: 29142747 PMCID: PMC5666660 DOI: 10.3892/mco.2017.1401

Abstract

The aim of the present study was to investigate the incidence of organ dysfunction, and to describe the clinical characteristics and intensive care unit (ICU) outcomes of critically ill cancer patients who were admitted to an oncological ICU during the isolated limb perfusion post-operative period. The present study was an observational investigation of 42 critically ill cancer patients who were admitted to the ICU of the Instituto Nacional de Cancerología, during the isolated limb perfusion post-operative period, between July 2010 and February 2016. The mean age of the patients was 45.7±16.9 years, and 45.2% (19 cases) were female. Soft tissue sarcoma was the most common pre-operative diagnosis (38.1%), and the mean duration of surgery was 267.6±50.1 min. Furthermore, a mean blood loss volume of 732.3±526.1 ml during the procedure was recorded, and the patients received a mean volume of 3.88±1.28 l crystalloid fluid during the surgical procedure, subsequently requiring an additional 2.95±6.28 l on the first post-operative day. The incidence of organ dysfunction was 90.5% and was most frequently noted in the respiratory (81%), hepatic (33%), hematologic (31%) and renal (11.9%) systems. No patients succumbed to the disease during the ICU and hospital stay. Nevertheless, <10% of the patients required vasopressors. Additionally, <5% of the patients required invasive mechanical ventilation. Therefore, ICU admission directly following isolated limb perfusion should not be standardized.

Keywords: critical care; critically ill cancer patients; intensive care; isolated limb perfusion; melphalan; tumor necrosis factor α

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