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Okabayashi Y, Tsuboi N, Sasaki T, et al. Glomerulopathy Associated With Moderate Obesity. Kidney Int Rep. 2016;1(4):250-255doi: 10.1016/j.ekir.2016.08.006.
Okabayashi, Y., Tsuboi, N., Sasaki, T., Haruhara, K., Kanzaki, G., Koike, K., Miyazaki, Y., Kawamura, T., Ogura, M., & Yokoo, T. (2016). Glomerulopathy Associated With Moderate Obesity. Kidney international reports, 1(4), 250-255. https://doi.org/10.1016/j.ekir.2016.08.006
Okabayashi, Yusuke, et al. "Glomerulopathy Associated With Moderate Obesity." Kidney international reports vol. 1,4 (2016): 250-255. doi: https://doi.org/10.1016/j.ekir.2016.08.006
Okabayashi Y, Tsuboi N, Sasaki T, Haruhara K, Kanzaki G, Koike K, Miyazaki Y, Kawamura T, Ogura M, Yokoo T. Glomerulopathy Associated With Moderate Obesity. Kidney Int Rep. 2016 Aug 12;1(4):250-255. doi: 10.1016/j.ekir.2016.08.006. eCollection 2016 Nov. PMID: 29142929; PMCID: PMC5678835.
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Kidney Int Rep. 2016 Aug 12;1(4):250-255. doi: 10.1016/j.ekir.2016.08.006. eCollection 2016 Nov.

Glomerulopathy Associated With Moderate Obesity.

Kidney international reports

Yusuke Okabayashi, Nobuo Tsuboi, Takaya Sasaki, Kotaro Haruhara, Go Kanzaki, Kentaro Koike, Yoichi Miyazaki, Tetsuya Kawamura, Makoto Ogura, Takashi Yokoo

Affiliations

  1. Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

PMID: 29142929 PMCID: PMC5678835 DOI: 10.1016/j.ekir.2016.08.006

Abstract

INTRODUCTION: Obesity-related glomerulopathy is an established secondary glomerular disease that may occur in obese individuals with a body mass index (BMI) of ≥30 kg/m

METHODS: A total of 20 patients with grade 1 obesity (25 ≤ BMI < 30 kg/m

RESULTS: Similar to the grade 2 or higher obesity group, the grade 1 obesity group had a male predominance (85%) and showed a high incidence of hypertension (80%). Urinary protein excretion and renal outcome parameters were comparable between the groups. Patients with grade 1 obesity showed typical histologic features of obesity-related glomerulopathy: low glomerular density with glomerulomegaly. The glomerular density and mean glomerular volume in the grade 1 group, the grade 2 or higher group, and the kidney transplant donors with grade 1 obesity were 1.6 ± 0.8 versus 1.4 ± 0.6 versus 3.0 ± 1.1 (per mm

DISCUSSION: A glomerulopathy similar to obesity-related glomerulopathy can occur in moderately obese individuals. Renal factor(s), such as low glomerular density, may thus underlie susceptibility to this disease entity as well as BMI.

Keywords: body mass index; glomerular density; hyperfiltration; obesity; renal biopsy

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