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Kidney Int Rep. 2017 Jan 26;2(3):420-424. doi: 10.1016/j.ekir.2017.01.008. eCollection 2017 May.

Elucidation of Renal Scars in Children With Vesicoureteral Reflux Using Contrast-Enhanced Ultrasound: A Pilot Study.

Kidney international reports

David S Hains, Harris L Cohen, M Beth McCarville, Ellen E Ellison, Amy Huffman, Stacey Glass, Aslam H Qureshi, Keith R Pierce, Ashlyn L Cahill, Ashley Dixon, Noel Delos Santos

Affiliations

  1. Center for Innate Immunity Translational Research, Children's Foundation Research Institute at Le Bonheur Children's Hospital, Memphis, Tennessee, USA.
  2. Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  3. Department of Radiology, Le Bonheur Children's Hospital, Memphis, Tennessee, USA.
  4. Department of Radiology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  5. Department of Diagnostic Imaging (MS 220), St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  6. Department of Urology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

PMID: 29142969 PMCID: PMC5678645 DOI: 10.1016/j.ekir.2017.01.008

Abstract

INTRODUCTION: Vesicoureteral reflux is a common disorder in children but can result in kidney scarring following acute pyelonephritis. The gold standard diagnostic to detect renal scars in children is

METHODS: In this study, we performed CEUS in 7 children with documented renal scars by radiographic imaging consistent with reflux nephropathy.

RESULTS: In all subjects, CEUS detected all previously known radiologic abnormalities as well as detecting new areas of hypoenhancing renal parenchyma. None of the patients experienced any serious adverse events.

DISCUSSION: This study represents the first report of using CEUS to characterize renal scars in children with reflux nephropathy. We conclude that CEUS is a highly sensitive, rapid, and cost-effective diagnostic imaging modality for detecting and monitoring renal scars in children with vesicoureteral reflux.

Keywords: contrast-enhanced ultrasound; reflux nephropathy; vesicoureteral reflux

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