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Hartmann K, Wooding A, Bergmann M. Efficacy of Antiviral Drugs against Feline Immunodeficiency Virus. Vet Sci. 2015;2(4):456-476doi: 10.3390/vetsci2040456.
Hartmann, K., Wooding, A., & Bergmann, M. (2015). Efficacy of Antiviral Drugs against Feline Immunodeficiency Virus. Veterinary sciences, 2(4), 456-476. https://doi.org/10.3390/vetsci2040456
Hartmann, Katrin, et al. "Efficacy of Antiviral Drugs against Feline Immunodeficiency Virus." Veterinary sciences vol. 2,4 (2015): 456-476. doi: https://doi.org/10.3390/vetsci2040456
Hartmann K, Wooding A, Bergmann M. Efficacy of Antiviral Drugs against Feline Immunodeficiency Virus. Vet Sci. 2015 Dec 18;2(4):456-476. doi: 10.3390/vetsci2040456. PMID: 29061953; PMCID: PMC5644647.
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Vet Sci. 2015 Dec 18;2(4):456-476. doi: 10.3390/vetsci2040456.

Efficacy of Antiviral Drugs against Feline Immunodeficiency Virus.

Veterinary sciences

Katrin Hartmann, Anita Wooding, Michèle Bergmann

Affiliations

  1. Clinic of Small Animal Medicine, LMU Munich, Veterinaerstrasse 13, 80539 Munich, Germany. [email protected].
  2. Clinic of Small Animal Medicine, LMU Munich, Veterinaerstrasse 13, 80539 Munich, Germany. [email protected].
  3. Clinic of Small Animal Medicine, LMU Munich, Veterinaerstrasse 13, 80539 Munich, Germany. [email protected].

PMID: 29061953 PMCID: PMC5644647 DOI: 10.3390/vetsci2040456

Abstract

Feline immunodeficiency virus (FIV) is one of the most common infectious agents affecting cats worldwide .FIV and human immunodeficiency virus (HIV) share many properties: both are lifelong persistent lentiviruses that are similar genetically and morphologically and both viruses propagate in T-lymphocytes, macrophages, and neural cells. Experimentally infected cats have measurable immune suppression, which sometimes progresses to an acquired immunodeficiency syndrome. A transient initial state of infection is followed by a long latent stage with low virus replication and absence of clinical signs. In the terminal stage, both viruses can cause severe immunosuppression. Thus, FIV infection in cats has become an important natural model for studying HIV infection in humans, especially for evaluation of antiviral compounds. Of particular importance for chemotherapeutic studies is the close similarity between the reverse transcriptase (RT) of FIV and HIV, which results in high

Keywords: FIV; antiviral compounds; therapy; treatment

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